Blood rheology in PCA and PCEA after total knee arthroplasty

Benzion Beilin*, Eduard Mayburd, Israel Zeev Yardeni, David Hendel, Dror Robinson, Hanna Bessler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The rheological events in 2 groups of patients undergoing total knee arthroplasty were compared-15 patients were given general anesthesia and controlled their postoperative pain applying intravenous patient-controlled analgesia; 17 individuals received combined spinal-epidural anesthesia and controlled their postoperative pain by patient-controlled epidural analgesia (PCEA). Twenty-four and 48 hours after surgery, the patient-controlled analgesia group showed a significant increase in whole-blood viscosity at the 3 shear rates (P < .01), as well as in relative viscosity at both periods (P < .001 and .01, respectively). Similar findings were observed for red blood cell aggregation (P < .001) and fibrinogen level (P < .001). These values were less expressed in the PCEA group, particularly 48 hours after surgery (P < .01), and the patients showed lower scores on the visual analog pain scale. The better results observed in the PCEA group favor the application of epidural anesthesia and PCEA analgesia in patients undergoing total knee arthroplasty.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalJournal of Arthroplasty
Issue number2
StatePublished - Feb 2006


  • Analgesia
  • Anesthesia
  • Rheology
  • TKA
  • Viscosity


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