Blood groups and their function

Marion E. Reid*, Vered Yahalom

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The function(s) assigned to red blood cell membrane components is based on an observed effect in the red cells that lack the component, comparison of the protein sequence (predicted from the nucleotide sequence of the gene) to proteins of known function, and extrapolation of function of the component in other cells. The functions are varied and include membrane structure, transport, receptor, adhesion, enzyme activity, complement components, complement regulation and glycocalyx formation. Several components have more than one function.

Original languageEnglish
Pages (from-to)485-509
Number of pages25
JournalBest Practice and Research: Clinical Haematology
Volume13
Issue number4
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Adhesion molecules
  • Blood groups
  • Function
  • Membrane proteins
  • Membrane structure
  • Receptors

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