Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers

Anna Malishkevich, Gad A. Marshall, Aaron P. Schultz, Reisa A. Sperling, Judith Aharon-Peretz, Illana Gozes

Research output: Contribution to journalArticlepeer-review

Abstract

Biomarkers for Alzheimer's disease (AD) are vital for disease detection in the clinical setting. Discovered in our laboratory, activity-dependent neuroprotective protein (ADNP) is essential for brain formation and linked to cognitive functions. Here, we revealed that blood borne expression of ADNP and its paralog ADNP2 is correlated with premorbid intelligence, AD pathology, and clinical stage. Age adjustment showed significant associations between: 1) higher premorbid intelligence and greater serum ADNP, and 2) greater cortical amyloid and lower ADNP and ADNP2 mRNAs. Significant increases in ADNP mRNA levels were observed in patients ranging from mild cognitive impairment (MCI) to AD dementia. ADNP2 transcripts showed high correlation with ADNP transcripts, especially in AD dementia lymphocytes. ADNP plasma/serum and lymphocyte mRNA levels discriminated well between cognitively normal elderly, MCI, and AD dementia participants. Measuring ADNP blood-borne levels could bring us a step closer to effectively screening and tracking AD.

Original languageEnglish
Pages (from-to)249-260
Number of pages12
JournalJournal of Alzheimer's Disease
Volume50
Issue number1
DOIs
StatePublished - 1 Jan 2016

Keywords

  • Activity-dependent neuroprotective protein (ADNP)
  • Alzheimer's disease
  • amyloid-beta
  • blood-borne biomarkers
  • cognitively normal
  • mild cognitive impairment
  • premorbid intelligence

Fingerprint

Dive into the research topics of 'Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers'. Together they form a unique fingerprint.

Cite this