Blastic crisis in previously clinically silent chronic myelogenous leukemia

U. Mintz, S. Bar Meir, M. Shaklai

Research output: Contribution to journalArticlepeer-review


A patient is described in whom CML fist presented as blastic crisis. The diagnosis of CML was based upon the findings of Ph1 chromosome in the bone marrow, basophilia in the peripheral blood, absence of neutrophil alkaline phosphatase (NAP) activity in the leukocytes, elevated serum vitamin B12 and an enlarged firm spleen. CML with blastic crisis as its first expression is relatively rare, as compared to CML in which blastic crisis appears as a phase of prolonged clinically manifest disease.

Original languageEnglish
Pages (from-to)257-260
Number of pages4
Issue number3-4
StatePublished - 1975


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