The title compound, bis[(-)-N-(trans-4-isopropylcyclohexanecarbonyl)-D- phenylalanine] hydronium chloride, 2C19H27NO 3·H3O+·Cl-, at 110 K contains four conformationally dissimilar moieties in the asymmetric unit, which are seemingly necessary in order to optimize the supramolecular association. The organic molecule forms O - H⋯O hydrogen-bonded carboxylic acid dimers, which are paired into six-component clusters via N - H⋯Cl hydrogen bonds through the two bridging chloride anions. These combined hexameric aggregates are further interlinked into extended two-dimensional network arrays via the hydronium ions by O - H⋯O and O - H⋯Cl hydrogen bonds. This study represents the first crystallographic report of nateglinide.
|Acta Crystallographica Section C: Crystal Structure Communications
|Published - Dec 2005