Bisdioxycalamenene: A bis-sesquiterpene from the soft coral Rhytisma fulvum fulvum

Yuval J. Trifman, Maurice Aknin, Anne Gauvin-Bialecki, Yehuda Benayahu, Shmuel Carmeli, Yoel Kashman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A dichloromethane extract of the soft coral Rhytisma fulvum fulvum collected inMadagascar afforded a novel compound possessing an unprecedented pentacyclic skeleton, bisdioxycalamenene (1), as well as seven known sesquiterpenes. The structures of the compounds were elucidated using 1D and 2D NMR techniques, as well as high-resolution mass spectrometry. The absolute configuration of 1 was determined using X-ray diffraction analysis and anomalous dispersion effects. The structure elucidation and a possible biogenesis of the compound are discussed.

Original languageEnglish
Article number41
JournalMarine Drugs
Issue number2
StatePublished - Feb 2016


  • Bis-sesquiterpene
  • Bisdioxycalamenene
  • Rhytisma fulvum fulvum
  • Soft coral


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