Birth weight- and fetal weight-growth restriction: Impact on neurodevelopment

Iris G. Streimish; Richard A. Ehrenkranz; Elizabeth N. Allred; T. Michael O'Shea; Karl C.K. Kuban; Nigel Paneth; Alan Leviton; Kristen Ecklund; Haim Bassan; Samantha Butler; Adré Duplessis; Cecil Hahn; Catherine Limperopoulos; Omar Khwaja; Janet S. Soul; Bhavesh Shah; Frederick Hampf; Herbert Gilmore; Susan McQuiston; Camilia R. Martin; Jane Share; Linda J. Van Marter; Sara Durfee; Robert M. Insoft; Sjirk J. Westra; Kalpathy Krishnamoorthy; Cynthia Cole; John M. Fiascone; Roy McCauley; Paige T. Church; Cecelia Keller; Karen J. Miller; Francis Bednarek; Jacqueline Wellman; Robin Adair; Bream Richard; Alice Miller; Albert Scheiner; Christy Stine; Richard A. Ehrenkranz; Cindy Miller; Nancy Close; Elaine Romano; Joanne Williams; Barbara Specter; Deborah Allred; Robert Dillard; Don Goldstein; Deborah Hiatt; Gail Hounshell; Ellen Waldrep; Lisa Washburn; Cherrie D. Welch; Stephen C. Engelke; Ira Adler; Sharon Buckwald; Rebecca Helms; Kathyrn Kerkering; Scott S. MacGilvray; Peter Resnik; Carl Bose; Lynn A. Fordham; Lisa Bostic; Diane Marshall; Kristi Milowic; Janice Wereszczak; Mariel Poortenga; Mariel Betz; Steven L. Bezinque; Joseph Junewick; Wendy Burdo-Hartman; Lynn Fagerman; Kim Lohr; Steve Pastyrnak; Dinah Sutton; Ellen Cavenagh; Victoria J. Caine; Nicholas Olomu; Joan Price; Nigel Paneth; Padmani Karna; Michael D. Schreiber; Kate Feinstein; Leslie Caldarelli; Sunila E. O'Connor; Michael Msall; Susan Plesha-Troyke; Daniel Batton; Karen Brooklier; Beth Kring; Melisa J. Oca; Katherine M. Solomon; Joanna J. Seibert; Robert Lorenzo

doi:10.1016/j.earlhumdev.2012.04.004

Birth weight- and fetal weight-growth restriction: Impact on neurodevelopment

Iris G. Streimish, Richard A. Ehrenkranz, Elizabeth N. Allred, T. Michael O'Shea, Karl C.K. Kuban, Nigel Paneth, Alan Leviton^*, Kristen Ecklund, Haim Bassan, Samantha Butler, Adré Duplessis, Cecil Hahn, Catherine Limperopoulos, Omar Khwaja, Janet S. Soul, Bhavesh Shah, Frederick Hampf, Herbert Gilmore, Susan McQuiston, Camilia R. MartinJane Share, Linda J. Van Marter, Sara Durfee, Robert M. Insoft, Sjirk J. Westra, Kalpathy Krishnamoorthy, Cynthia Cole, John M. Fiascone, Roy McCauley, Paige T. Church, Cecelia Keller, Karen J. Miller, Francis Bednarek, Jacqueline Wellman, Robin Adair, Bream Richard, Alice Miller, Albert Scheiner, Christy Stine, Richard A. Ehrenkranz, Cindy Miller, Nancy Close, Elaine Romano, Joanne Williams, Barbara Specter, Deborah Allred, Robert Dillard, Don Goldstein, Deborah Hiatt, Gail Hounshell, Ellen Waldrep, Lisa Washburn, Cherrie D. Welch, Stephen C. Engelke, Ira Adler, Sharon Buckwald, Rebecca Helms, Kathyrn Kerkering, Scott S. MacGilvray, Peter Resnik, Carl Bose, Lynn A. Fordham, Lisa Bostic, Diane Marshall, Kristi Milowic, Janice Wereszczak, Mariel Poortenga, Mariel Betz, Steven L. Bezinque, Joseph Junewick, Wendy Burdo-Hartman, Lynn Fagerman, Kim Lohr, Steve Pastyrnak, Dinah Sutton, Ellen Cavenagh, Victoria J. Caine, Nicholas Olomu, Joan Price, Nigel Paneth, Padmani Karna, Michael D. Schreiber, Kate Feinstein, Leslie Caldarelli, Sunila E. O'Connor, Michael Msall, Susan Plesha-Troyke, Daniel Batton, Karen Brooklier, Beth Kring, Melisa J. Oca, Katherine M. Solomon, Joanna J. Seibert, Robert Lorenzo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Background: The newborn classified as growth-restricted on fetal weight curves, but not on birth weight curves, is classified prenatally as small for gestational age (SGA), but postnatally as appropriate for gestational age (AGA). Aims: To see (1) to what extent the neurodevelopmental outcomes at 24. months corrected age differed among three groups of infants (those identified as SGA based on birth weight curves (B-SGA), those identified as SGA based on fetal weight curves only (F-SGA), and the referent group of infants considered AGA, (2) if girls and boys were equally affected by growth restriction, and (3) to what extent neurosensory limitations influenced what we found. Study design: Observational cohort of births before the 28th week of gestation. Outcome measures: Mental Development Index (MDI) and Psychomotor Development Index (PDI) of the Bayley Scales of Infant Development II. Results: B-SGA, but not F-SGA girls were at an increased risk of a PDI < 70 (OR = 2.8; 95% CI: 1.5, 5.3) compared to AGA girls. B-SGA and F-SGA boys were not at greater risk of low developmental indices than AGA boys. Neurosensory limitations diminished associations among girls of B-SGA with low MDI, and among boys B-SGA and F-SGA with PDI < 70. Conclusions: Only girls with the most severe growth restriction were at increased risk of neurodevelopmental impairment at 24. months corrected age in the total sample. Neurosensory limitations appear to interfere with assessing growth restriction effects in both girls and boys born preterm.

Original language	English
Pages (from-to)	765-771
Number of pages	7
Journal	Early Human Development
Volume	88
Issue number	9
DOIs	https://doi.org/10.1016/j.earlhumdev.2012.04.004
State	Published - 1 Sep 2012
Externally published	Yes

Funding

Funders	Funder number
National Institute of Neurological Disorders and Stroke	U01NS040069
National Institute of Child Health and Human Development	5P30HD018655-28
Agency for Healthcare Research and Quality	2T32HS00006D-16
Eunice Kennedy Shriver National Institute of Child Health and Human Development	T32 HD07094

Keywords

Cognition disorders/epidemiology
Fetal growth retardation/epidemiology
Follow-up studies
Gestational age
Infant
Premature

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10.1016/j.earlhumdev.2012.04.004

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Streimish, I. G., Ehrenkranz, R. A., Allred, E. N., O'Shea, T. M., Kuban, K. C. K., Paneth, N., Leviton, A., Ecklund, K., Bassan, H., Butler, S., Duplessis, A., Hahn, C., Limperopoulos, C., Khwaja, O., Soul, J. S., Shah, B., Hampf, F., Gilmore, H., McQuiston, S., ... Lorenzo, R. (2012). Birth weight- and fetal weight-growth restriction: Impact on neurodevelopment. Early Human Development, 88(9), 765-771. https://doi.org/10.1016/j.earlhumdev.2012.04.004

@article{ea51745869764109adc1a224702378c4,

title = "Birth weight- and fetal weight-growth restriction: Impact on neurodevelopment",

abstract = "Background: The newborn classified as growth-restricted on fetal weight curves, but not on birth weight curves, is classified prenatally as small for gestational age (SGA), but postnatally as appropriate for gestational age (AGA). Aims: To see (1) to what extent the neurodevelopmental outcomes at 24. months corrected age differed among three groups of infants (those identified as SGA based on birth weight curves (B-SGA), those identified as SGA based on fetal weight curves only (F-SGA), and the referent group of infants considered AGA, (2) if girls and boys were equally affected by growth restriction, and (3) to what extent neurosensory limitations influenced what we found. Study design: Observational cohort of births before the 28th week of gestation. Outcome measures: Mental Development Index (MDI) and Psychomotor Development Index (PDI) of the Bayley Scales of Infant Development II. Results: B-SGA, but not F-SGA girls were at an increased risk of a PDI < 70 (OR = 2.8; 95% CI: 1.5, 5.3) compared to AGA girls. B-SGA and F-SGA boys were not at greater risk of low developmental indices than AGA boys. Neurosensory limitations diminished associations among girls of B-SGA with low MDI, and among boys B-SGA and F-SGA with PDI < 70. Conclusions: Only girls with the most severe growth restriction were at increased risk of neurodevelopmental impairment at 24. months corrected age in the total sample. Neurosensory limitations appear to interfere with assessing growth restriction effects in both girls and boys born preterm.",

keywords = "Cognition disorders/epidemiology, Fetal growth retardation/epidemiology, Follow-up studies, Gestational age, Infant, Premature",

author = "Streimish, {Iris G.} and Ehrenkranz, {Richard A.} and Allred, {Elizabeth N.} and O'Shea, {T. Michael} and Kuban, {Karl C.K.} and Nigel Paneth and Alan Leviton and Kristen Ecklund and Haim Bassan and Samantha Butler and Adr{\'e} Duplessis and Cecil Hahn and Catherine Limperopoulos and Omar Khwaja and Soul, {Janet S.} and Bhavesh Shah and Frederick Hampf and Herbert Gilmore and Susan McQuiston and Martin, {Camilia R.} and Jane Share and {Van Marter}, {Linda J.} and Sara Durfee and Insoft, {Robert M.} and Westra, {Sjirk J.} and Kalpathy Krishnamoorthy and Cynthia Cole and Fiascone, {John M.} and Roy McCauley and Church, {Paige T.} and Cecelia Keller and Miller, {Karen J.} and Francis Bednarek and Jacqueline Wellman and Robin Adair and Bream Richard and Alice Miller and Albert Scheiner and Christy Stine and Ehrenkranz, {Richard A.} and Cindy Miller and Nancy Close and Elaine Romano and Joanne Williams and Barbara Specter and Deborah Allred and Robert Dillard and Don Goldstein and Deborah Hiatt and Gail Hounshell and Ellen Waldrep and Lisa Washburn and Welch, {Cherrie D.} and Engelke, {Stephen C.} and Ira Adler and Sharon Buckwald and Rebecca Helms and Kathyrn Kerkering and MacGilvray, {Scott S.} and Peter Resnik and Carl Bose and Fordham, {Lynn A.} and Lisa Bostic and Diane Marshall and Kristi Milowic and Janice Wereszczak and Mariel Poortenga and Mariel Betz and Bezinque, {Steven L.} and Joseph Junewick and Wendy Burdo-Hartman and Lynn Fagerman and Kim Lohr and Steve Pastyrnak and Dinah Sutton and Ellen Cavenagh and Caine, {Victoria J.} and Nicholas Olomu and Joan Price and Nigel Paneth and Padmani Karna and Schreiber, {Michael D.} and Kate Feinstein and Leslie Caldarelli and O'Connor, {Sunila E.} and Michael Msall and Susan Plesha-Troyke and Daniel Batton and Karen Brooklier and Beth Kring and Oca, {Melisa J.} and Solomon, {Katherine M.} and Seibert, {Joanna J.} and Robert Lorenzo",

note = "Funding Information: This study was supported by a cooperative agreement with the National Institute of Neurological Diseases and Stroke ( 5U01NS040069-05 ) and a center grant award from the National Institute of Child Health and Human Development ( 5P30HD018655-28 ). Dr. Streimish was supported by training grants from Eunice Shriver National Institute of Child Health and Human Development ( T32 HD07094 ) and the Agency for Healthcare Research and Quality ( 2T32HS00006D-16 ). The authors gratefully acknowledge the contributions of their subjects, and their subjects' families, as well as those of their colleagues. ",

year = "2012",

month = sep,

day = "1",

doi = "10.1016/j.earlhumdev.2012.04.004",

language = "אנגלית",

volume = "88",

pages = "765--771",

journal = "Early Human Development",

issn = "0378-3782",

publisher = "Elsevier Ireland Ltd",

number = "9",

}

Streimish, IG, Ehrenkranz, RA, Allred, EN, O'Shea, TM, Kuban, KCK, Paneth, N, Leviton, A, Ecklund, K, Bassan, H, Butler, S, Duplessis, A, Hahn, C, Limperopoulos, C, Khwaja, O, Soul, JS, Shah, B, Hampf, F, Gilmore, H, McQuiston, S, Martin, CR, Share, J, Van Marter, LJ, Durfee, S, Insoft, RM, Westra, SJ, Krishnamoorthy, K, Cole, C, Fiascone, JM, McCauley, R, Church, PT, Keller, C, Miller, KJ, Bednarek, F, Wellman, J, Adair, R, Richard, B, Miller, A, Scheiner, A, Stine, C, Ehrenkranz, RA, Miller, C, Close, N, Romano, E, Williams, J, Specter, B, Allred, D, Dillard, R, Goldstein, D, Hiatt, D, Hounshell, G, Waldrep, E, Washburn, L, Welch, CD, Engelke, SC, Adler, I, Buckwald, S, Helms, R, Kerkering, K, MacGilvray, SS, Resnik, P, Bose, C, Fordham, LA, Bostic, L, Marshall, D, Milowic, K, Wereszczak, J, Poortenga, M, Betz, M, Bezinque, SL, Junewick, J, Burdo-Hartman, W, Fagerman, L, Lohr, K, Pastyrnak, S, Sutton, D, Cavenagh, E, Caine, VJ, Olomu, N, Price, J, Paneth, N, Karna, P, Schreiber, MD, Feinstein, K, Caldarelli, L, O'Connor, SE, Msall, M, Plesha-Troyke, S, Batton, D, Brooklier, K, Kring, B, Oca, MJ, Solomon, KM, Seibert, JJ & Lorenzo, R 2012, 'Birth weight- and fetal weight-growth restriction: Impact on neurodevelopment', Early Human Development, vol. 88, no. 9, pp. 765-771. https://doi.org/10.1016/j.earlhumdev.2012.04.004

TY - JOUR

T1 - Birth weight- and fetal weight-growth restriction

T2 - Impact on neurodevelopment

AU - Streimish, Iris G.

AU - Ehrenkranz, Richard A.

AU - Allred, Elizabeth N.

AU - O'Shea, T. Michael

AU - Kuban, Karl C.K.

AU - Paneth, Nigel

AU - Leviton, Alan

AU - Ecklund, Kristen

AU - Bassan, Haim

AU - Butler, Samantha

AU - Duplessis, Adré

AU - Hahn, Cecil

AU - Limperopoulos, Catherine

AU - Khwaja, Omar

AU - Soul, Janet S.

AU - Shah, Bhavesh

AU - Hampf, Frederick

AU - Gilmore, Herbert

AU - McQuiston, Susan

AU - Martin, Camilia R.

AU - Share, Jane

AU - Van Marter, Linda J.

AU - Durfee, Sara

AU - Insoft, Robert M.

AU - Westra, Sjirk J.

AU - Krishnamoorthy, Kalpathy

AU - Cole, Cynthia

AU - Fiascone, John M.

AU - McCauley, Roy

AU - Church, Paige T.

AU - Keller, Cecelia

AU - Miller, Karen J.

AU - Bednarek, Francis

AU - Wellman, Jacqueline

AU - Adair, Robin

AU - Richard, Bream

AU - Miller, Alice

AU - Scheiner, Albert

AU - Stine, Christy

AU - Ehrenkranz, Richard A.

AU - Miller, Cindy

AU - Close, Nancy

AU - Romano, Elaine

AU - Williams, Joanne

AU - Specter, Barbara

AU - Allred, Deborah

AU - Dillard, Robert

AU - Goldstein, Don

AU - Hiatt, Deborah

AU - Hounshell, Gail

AU - Waldrep, Ellen

AU - Washburn, Lisa

AU - Welch, Cherrie D.

AU - Engelke, Stephen C.

AU - Adler, Ira

AU - Buckwald, Sharon

AU - Helms, Rebecca

AU - Kerkering, Kathyrn

AU - MacGilvray, Scott S.

AU - Resnik, Peter

AU - Bose, Carl

AU - Fordham, Lynn A.

AU - Bostic, Lisa

AU - Marshall, Diane

AU - Milowic, Kristi

AU - Wereszczak, Janice

AU - Poortenga, Mariel

AU - Betz, Mariel

AU - Bezinque, Steven L.

AU - Junewick, Joseph

AU - Burdo-Hartman, Wendy

AU - Fagerman, Lynn

AU - Lohr, Kim

AU - Pastyrnak, Steve

AU - Sutton, Dinah

AU - Cavenagh, Ellen

AU - Caine, Victoria J.

AU - Olomu, Nicholas

AU - Price, Joan

AU - Paneth, Nigel

AU - Karna, Padmani

AU - Schreiber, Michael D.

AU - Feinstein, Kate

AU - Caldarelli, Leslie

AU - O'Connor, Sunila E.

AU - Msall, Michael

AU - Plesha-Troyke, Susan

AU - Batton, Daniel

AU - Brooklier, Karen

AU - Kring, Beth

AU - Oca, Melisa J.

AU - Solomon, Katherine M.

AU - Seibert, Joanna J.

AU - Lorenzo, Robert

N1 - Funding Information: This study was supported by a cooperative agreement with the National Institute of Neurological Diseases and Stroke ( 5U01NS040069-05 ) and a center grant award from the National Institute of Child Health and Human Development ( 5P30HD018655-28 ). Dr. Streimish was supported by training grants from Eunice Shriver National Institute of Child Health and Human Development ( T32 HD07094 ) and the Agency for Healthcare Research and Quality ( 2T32HS00006D-16 ). The authors gratefully acknowledge the contributions of their subjects, and their subjects' families, as well as those of their colleagues.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Background: The newborn classified as growth-restricted on fetal weight curves, but not on birth weight curves, is classified prenatally as small for gestational age (SGA), but postnatally as appropriate for gestational age (AGA). Aims: To see (1) to what extent the neurodevelopmental outcomes at 24. months corrected age differed among three groups of infants (those identified as SGA based on birth weight curves (B-SGA), those identified as SGA based on fetal weight curves only (F-SGA), and the referent group of infants considered AGA, (2) if girls and boys were equally affected by growth restriction, and (3) to what extent neurosensory limitations influenced what we found. Study design: Observational cohort of births before the 28th week of gestation. Outcome measures: Mental Development Index (MDI) and Psychomotor Development Index (PDI) of the Bayley Scales of Infant Development II. Results: B-SGA, but not F-SGA girls were at an increased risk of a PDI < 70 (OR = 2.8; 95% CI: 1.5, 5.3) compared to AGA girls. B-SGA and F-SGA boys were not at greater risk of low developmental indices than AGA boys. Neurosensory limitations diminished associations among girls of B-SGA with low MDI, and among boys B-SGA and F-SGA with PDI < 70. Conclusions: Only girls with the most severe growth restriction were at increased risk of neurodevelopmental impairment at 24. months corrected age in the total sample. Neurosensory limitations appear to interfere with assessing growth restriction effects in both girls and boys born preterm.

AB - Background: The newborn classified as growth-restricted on fetal weight curves, but not on birth weight curves, is classified prenatally as small for gestational age (SGA), but postnatally as appropriate for gestational age (AGA). Aims: To see (1) to what extent the neurodevelopmental outcomes at 24. months corrected age differed among three groups of infants (those identified as SGA based on birth weight curves (B-SGA), those identified as SGA based on fetal weight curves only (F-SGA), and the referent group of infants considered AGA, (2) if girls and boys were equally affected by growth restriction, and (3) to what extent neurosensory limitations influenced what we found. Study design: Observational cohort of births before the 28th week of gestation. Outcome measures: Mental Development Index (MDI) and Psychomotor Development Index (PDI) of the Bayley Scales of Infant Development II. Results: B-SGA, but not F-SGA girls were at an increased risk of a PDI < 70 (OR = 2.8; 95% CI: 1.5, 5.3) compared to AGA girls. B-SGA and F-SGA boys were not at greater risk of low developmental indices than AGA boys. Neurosensory limitations diminished associations among girls of B-SGA with low MDI, and among boys B-SGA and F-SGA with PDI < 70. Conclusions: Only girls with the most severe growth restriction were at increased risk of neurodevelopmental impairment at 24. months corrected age in the total sample. Neurosensory limitations appear to interfere with assessing growth restriction effects in both girls and boys born preterm.

KW - Cognition disorders/epidemiology

KW - Fetal growth retardation/epidemiology

KW - Follow-up studies

KW - Gestational age

KW - Infant

KW - Premature

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AN - SCOPUS:84864031016

SN - 0378-3782

VL - 88

SP - 765

EP - 771

JO - Early Human Development

JF - Early Human Development

IS - 9

ER -

Birth weight- and fetal weight-growth restriction: Impact on neurodevelopment

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