Bipolar affective disorder heralding cerebral demyelination in adreno- myelo-leukodystrophy

Doron Gothelf, Ronen Levite, Natan Gadoth

Research output: Contribution to journalArticlepeer-review


A young male with adrenomyeloleukodystrophy (AMLD), diagnosed at the age of 25 years, presented with signs of bipolar affective disorder (BPD) concomitant with radiological findings of central demyelination. There was a marked deterioration of the earlier relatively benign neurological dysfunction, leading to fatal bulbar syndrome. The association of BPD with central demyelination in AMLD is in agreement with previously reported cases of this and other types of multifocal central demyelination diseases. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)184-187
Number of pages4
JournalBrain and Development
Issue number3
StatePublished - 24 May 2000
Externally publishedYes


  • Adrenal
  • Affective disorder
  • Depression
  • Leukodystrophy
  • Mania
  • Myelin


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