Biosynthesis of tolytoxin. Origin of the carbons and heteroatoms

Shmuel Carmeli*, Richard E. Moore, Gregory M.L. Patterson, Wesley Y. Yoshida

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Preliminary studies on the biosynthesis of tolytoxin (1) in the terrestrial blue-green alga Scytonema mirabile BY-8-1 are reported. Incorporation experiments with [1,2-13C] acetate, [1-13C,18O]acetate, [1,2-13C]glycine, [2-13C,15N]glycine and [methyl- 13C]methionine indicate that the carbon chain of tolytoxin is a polyketide assembled from a glycine starter unit and 15 acetate units. The one-carbon branches on the polyketide chain originate from the tetrahydrofolate C1 pool.

Original languageEnglish
Pages (from-to)5571-5574
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number35
DOIs
StatePublished - 27 Aug 1993

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