TY - JOUR
T1 - Biosynthesis of Thiamine. Inhibition of Thiamine Phosphatase Activity by Pyridoxal
AU - Lewin, Lawrence M.
N1 - Funding Information:
The biosynthesis of thiamine from 2-methyl-4-amino-5-hydroxymethylpyrimidine and 4-methyl-5-(hydroxyethyl) thiazole, or from their pyro-and monophosphate esters respectively, was inhibited by pyridoxal. Pyridoxal was shown to inhibit the conversion of thiamine monophosphate to thiamine by a cell-free enzyme system prepared from baker's yeast. The author wishes to thank Mr. Robert Wei and Mr. Robert Domush for skillful technical assistance in this work, which was supported, in part, by grant AM-08393 from Nat. Inst. of Health, U.S.P.H.S.
PY - 1967/1
Y1 - 1967/1
N2 - The biosynthesis of thiamine from 2-methyl-4-amino-5-hydroxymethylpyrimidine and 4-methyl-5-(hydroxyethyl) thiazole, or from their pyro-and monophosphate esters respectively, was inhibited by pyridoxal. Pyridoxal was shown to inhibit the conversion of thiamine monophosphate to thiamine by a cell-free enzyme system prepared from baker's yeast. The author wishes to thank Mr. Robert Wei and Mr. Robert Domush for skillful technical assistance in this work, which was supported, in part, by grant AM-08393 from Nat. Inst. of Health, U.S.P.H.S.
AB - The biosynthesis of thiamine from 2-methyl-4-amino-5-hydroxymethylpyrimidine and 4-methyl-5-(hydroxyethyl) thiazole, or from their pyro-and monophosphate esters respectively, was inhibited by pyridoxal. Pyridoxal was shown to inhibit the conversion of thiamine monophosphate to thiamine by a cell-free enzyme system prepared from baker's yeast. The author wishes to thank Mr. Robert Wei and Mr. Robert Domush for skillful technical assistance in this work, which was supported, in part, by grant AM-08393 from Nat. Inst. of Health, U.S.P.H.S.
UR - http://www.scopus.com/inward/record.url?scp=0014035535&partnerID=8YFLogxK
U2 - 10.3181/00379727-124-31661
DO - 10.3181/00379727-124-31661
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AN - SCOPUS:0014035535
VL - 124
SP - 39
EP - 43
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
SN - 1535-3702
IS - 1
ER -