Biosynthesis of Thiamine. Inhibition of Thiamine Phosphatase Activity by Pyridoxal

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Abstract

The biosynthesis of thiamine from 2-methyl-4-amino-5-hydroxymethylpyrimidine and 4-methyl-5-(hydroxyethyl) thiazole, or from their pyro-and monophosphate esters respectively, was inhibited by pyridoxal. Pyridoxal was shown to inhibit the conversion of thiamine monophosphate to thiamine by a cell-free enzyme system prepared from baker's yeast. The author wishes to thank Mr. Robert Wei and Mr. Robert Domush for skillful technical assistance in this work, which was supported, in part, by grant AM-08393 from Nat. Inst. of Health, U.S.P.H.S.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalExperimental Biology and Medicine
Volume124
Issue number1
DOIs
StatePublished - Jan 1967

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