TY - JOUR
T1 - Biosynthesis of 11-deoxycorticosterone by the ovary of the yucca night lizard, Xantusia vigilis
AU - Colombo, Lorenzo
AU - Yaron, Zvi
AU - Daniels, Ellen
AU - Belvedere, Paola
PY - 1974/11
Y1 - 1974/11
N2 - The steroidogenic capability of the fully grown ovaries of the lizard Xantusia vigilis was studied in vitro using pregnenolone-4-14C as a precursor. The following metabolites were identified in the incubate by their isopolarity and isomorphicity with standard compounds: predominantly progesterone and 11-deoxycorticosterone and smaller amounts of androstenedione. Testosterone was absent and 17α-hydroxylated intermediates could not be isolated. The enzyme steroid 21-hydroxylase, essential for the formation of 11-deoxycorticosterone, is reported for the first time in the ovary of a reptile.
AB - The steroidogenic capability of the fully grown ovaries of the lizard Xantusia vigilis was studied in vitro using pregnenolone-4-14C as a precursor. The following metabolites were identified in the incubate by their isopolarity and isomorphicity with standard compounds: predominantly progesterone and 11-deoxycorticosterone and smaller amounts of androstenedione. Testosterone was absent and 17α-hydroxylated intermediates could not be isolated. The enzyme steroid 21-hydroxylase, essential for the formation of 11-deoxycorticosterone, is reported for the first time in the ovary of a reptile.
UR - http://www.scopus.com/inward/record.url?scp=0016309431&partnerID=8YFLogxK
U2 - 10.1016/0016-6480(74)90187-7
DO - 10.1016/0016-6480(74)90187-7
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AN - SCOPUS:0016309431
SN - 0016-6480
VL - 24
SP - 331
EP - 337
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
IS - 3
ER -