Biophysics of TRP channels

M. Parnas, M. Peters, B. Minke

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Transient receptor potential (TRP) proteins are polymodal channels involved in a wide variety of cellular processes, mainly by changing membrane voltage and increasing cellular calcium concentrations. This chapter outlines biophysical properties of TRP channels, including (1) Structural features such as heteromultimerization, subunits in channel assembly and modular nature, (2) voltage and Ca2+ dependence, including intrinsic versus nonintrinsic voltage dependence arising from divalent cation open channel block, (3) activation and regulation mechanisms including thermosensation, chemical sensing (agonists and antagonists), mechanosensitivity, allosteric gating mechanism, and translocation, (4) regulation and activation by phosphoinositides (especially PIP2) and the crucial role of phospholipase C, and (5) physiological implications and TRP integrative function.

Original languageEnglish
Title of host publicationComprehensive Biophysics
PublisherElsevier Inc.
Pages68-107
Number of pages40
Volume6
ISBN (Print)9780080957180
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • Allosteric gating mechanism
  • Chemical Sensing
  • Drosophila TRP and TRPL channels
  • Heteromultimerization
  • Lipid rafts
  • Mechanosensitivity
  • Phosphoinositides
  • TRP channels
  • TRP modules
  • Thermosensation
  • Translocation
  • Voltage dependence

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