Biophysical shunt theory for neuropsychopathology: Biphasal homeostatic dysregulation

Y. Naisberg, A. Weizman

Research output: Contribution to journalArticlepeer-review


Objective: We challenge Freud's psychodynamic theory using a systematic modus operandi which has been outlined in detail in a succession of articles. Here, we deal with Freud's first assumption of human psychological primacy in forming goal-directed behavior. According to our theory, biphasal homeostatic dysregulation is the underlying mechanism of clinical phenomenology. Model: Evolutionary neurobiology has provided humans with a precise technical solution for optimal organismic survival. Humans are armed with an accurate negative feedback mechanism that operates within the alternating upper and lower thresholds of biphasal homeostatic maintenance and is coupled with a basal indicator of individual sensation of the degree of the given organismic well-being in any unit of time. This originates the organismic pleasure principle (OPP). The latter is achieved by a straightforward quantal injection of endorphins according to one of eight possible body operational regimens. Thanks to the essential duality of the dynamic interactions, stipulated by the complex harmonics of term-dependent and event-dependent adaptation when one or more of the essential elements for homeostasis goes above or below its predetermined threshold, certain branches of the organismic defense system (ODS) are 'turned on' in the second phase of homeostasis. The individual then adapts behavioral modifications directed toward a long-lasting search for the optimal resources needed for normal survival. This evolutionary biphasal homeostatic design has an intrinsic, methodical expression that confirms changes and correctly informs the individual about them, further imposing behavioral modifications, when necessary. In cases of a homeostatic derangement, the OPP is replaced by an erratic inclusion of pain, tension or depression, all components of the alarm system of the ODS, which may lead to disordered behavioral patterns. Conclusions: The underlying biological mechanism of goal-directed assignments for biphasal homeostatic maintenance is described. The intrinsic rules and regulations that guide both normal and abnormal survival may be clinically manifest. Normal survival behavior is necessary to regain organismic homeostasis.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalMedical Hypotheses
Issue number3
StatePublished - Mar 1999


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