Biomolecular magic-angle spinning solid-state NMR: Recent methods and applications

Amir Goldbourt*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The link of structure and dynamics of biomolecules and their complexes to their function and to many cellular processes has driven the quest for their detailed characterization by a variety of biophysical techniques. Magic-angle spinning solid-state nuclear magnetic resonance spectroscopy provides detailed information on the structural properties of such systems and in particular contributes invaluable information on non-soluble, large molecular-weight and non-crystalline biomolecules. This review summarizes the recent progress that has been made in the characterization of macromolecular assemblies, viruses, membrane proteins, amyloid fibrils, protein aggregates and more by magic-angle spinning solid-state NMR.

Original languageEnglish
Pages (from-to)705-715
Number of pages11
JournalCurrent Opinion in Biotechnology
Volume24
Issue number4
DOIs
StatePublished - Aug 2013

Funding

FundersFunder number
National Institute for Psychobiology in Israel
Israel Science FoundationEU-FP7-IRG

    Fingerprint

    Dive into the research topics of 'Biomolecular magic-angle spinning solid-state NMR: Recent methods and applications'. Together they form a unique fingerprint.

    Cite this