TY - JOUR
T1 - Biomimetic synthesis of pyrido [2,3,4-kl]acridines
AU - Gellerman, Gari
AU - Rudi, Amira
AU - Kashman, Yoel
PY - 1993/3/12
Y1 - 1993/3/12
N2 - A short new biomimetic route to the pyrido[2,3,4-kl]acridine ring system has been developed from readily available benzoquinone, or hydroquinone precursors, and β,β′-diaminoketones like kynuramine (3) or 2,2′-diaminobenzophenone (4), involving one key step. Pyrido[2,3,4-kl]acridine and closely related compounds have been prepared (5-9). The reaction has been shown to proceed to the formation of 1:1 and/or 1:2 quinone/amine adducts. Using of o-aminoacetophenone afforded dibenzo[1,10]phenanthrolinedione (11) a potential intermediate to eilatin 2.
AB - A short new biomimetic route to the pyrido[2,3,4-kl]acridine ring system has been developed from readily available benzoquinone, or hydroquinone precursors, and β,β′-diaminoketones like kynuramine (3) or 2,2′-diaminobenzophenone (4), involving one key step. Pyrido[2,3,4-kl]acridine and closely related compounds have been prepared (5-9). The reaction has been shown to proceed to the formation of 1:1 and/or 1:2 quinone/amine adducts. Using of o-aminoacetophenone afforded dibenzo[1,10]phenanthrolinedione (11) a potential intermediate to eilatin 2.
UR - http://www.scopus.com/inward/record.url?scp=0027474403&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(00)60789-X
DO - 10.1016/S0040-4039(00)60789-X
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AN - SCOPUS:0027474403
SN - 0040-4039
VL - 34
SP - 1823
EP - 1826
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 11
ER -