Biomimetic peptide self-assembly for functional materials

Aviad Levin, Tuuli A. Hakala, Lee Schnaider, Gonçalo J.L. Bernardes, Ehud Gazit, Tuomas P.J. Knowles*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Natural biomolecular systems have evolved to form a rich variety of supramolecular materials and machinery fundamental to cellular function. The assembly of these structures commonly involves interactions between specific molecular building blocks, a strategy that can also be replicated in an artificial setting to prepare functional materials. The self-assembly of synthetic biomimetic peptides thus allows the exploration of chemical and sequence space beyond that used routinely by biology. In this Review, we discuss recent conceptual and experimental advances in self-assembling artificial peptidic materials. In particular, we explore how naturally occurring structures and phenomena have inspired the development of functional biomimetic materials that we can harness for potential interactions with biological systems. As our fundamental understanding of peptide self-assembly evolves, increasingly sophisticated materials and applications emerge and lead to the development of a new set of building blocks and assembly principles relevant to materials science, molecular biology, nanotechnology and precision medicine. [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)615-634
Number of pages20
JournalNature Reviews Chemistry
Issue number11
StatePublished - 1 Nov 2020


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