Biomimetic Glyconanoparticle Nanoghost Vaccine Based on Red Blood Cells

Nofar Israel; Shani Leviatan Ben-Arye; Andrea Perota; Cesare Galli; Vered Padler-Karavani

doi:10.1007/978-1-0716-4542-0_11

Biomimetic Glyconanoparticle Nanoghost Vaccine Based on Red Blood Cells

Nofar Israel, Shani Leviatan Ben-Arye, Andrea Perota, Cesare Galli, Vered Padler-Karavani

The Shmunis School of Biomedicine and Cancer Research

Avantea

Research output: Contribution to journal › Article › peer-review

Abstract

Cancer vaccine is an active immunotherapy approach that aims to stimulate the host's immune responses toward specific targets on cancer cells, to direct their killing. Cancer cells commonly express aberrant cell surface glycosylation that support their immune evasion. Therefore, cancer glycosylation could be used as an efficient target for therapy. Lipid-based glyconanoparticles that express cancer glycosylation could mimic cancer cells and be used as therapeutic cancer vaccines. Here, we describe generation of biomimetic glyconanoparticles cancer vaccine based on porcine red blood cells that express cancer glycosylation containing the dietary nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc).

Original language	English
Pages (from-to)	143-156
Number of pages	14
Journal	Methods in Molecular Biology
Volume	2926
DOIs	https://doi.org/10.1007/978-1-0716-4542-0_11
State	Published - 2025

Keywords

Biomimetic
Cancer vaccine
Glycan microarray
Glyconanoparticle
N-glycolylneuraminic acid (Neu5Gc)
Sialic acid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-0716-4542-0_11

Cite this

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title = "Biomimetic Glyconanoparticle Nanoghost Vaccine Based on Red Blood Cells",

abstract = "Cancer vaccine is an active immunotherapy approach that aims to stimulate the host's immune responses toward specific targets on cancer cells, to direct their killing. Cancer cells commonly express aberrant cell surface glycosylation that support their immune evasion. Therefore, cancer glycosylation could be used as an efficient target for therapy. Lipid-based glyconanoparticles that express cancer glycosylation could mimic cancer cells and be used as therapeutic cancer vaccines. Here, we describe generation of biomimetic glyconanoparticles cancer vaccine based on porcine red blood cells that express cancer glycosylation containing the dietary nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc).",

keywords = "Biomimetic, Cancer vaccine, Glycan microarray, Glyconanoparticle, N-glycolylneuraminic acid (Neu5Gc), Sialic acid",

author = "Nofar Israel and {Leviatan Ben-Arye}, Shani and Andrea Perota and Cesare Galli and Vered Padler-Karavani",

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doi = "10.1007/978-1-0716-4542-0_11",

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AU - Perota, Andrea

AU - Galli, Cesare

AU - Padler-Karavani, Vered

PY - 2025

Y1 - 2025

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AB - Cancer vaccine is an active immunotherapy approach that aims to stimulate the host's immune responses toward specific targets on cancer cells, to direct their killing. Cancer cells commonly express aberrant cell surface glycosylation that support their immune evasion. Therefore, cancer glycosylation could be used as an efficient target for therapy. Lipid-based glyconanoparticles that express cancer glycosylation could mimic cancer cells and be used as therapeutic cancer vaccines. Here, we describe generation of biomimetic glyconanoparticles cancer vaccine based on porcine red blood cells that express cancer glycosylation containing the dietary nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc).

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KW - Cancer vaccine

KW - Glycan microarray

KW - Glyconanoparticle

KW - N-glycolylneuraminic acid (Neu5Gc)

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Biomimetic Glyconanoparticle Nanoghost Vaccine Based on Red Blood Cells

Abstract

Keywords

UN SDGs

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