TY - GEN
T1 - Biomechanical modeling of an alveolar sac for simulation of septal stresses in pulmonary edema
AU - Gefen, Amit
AU - Elad, David
AU - Shiner, Robert J.
PY - 1999
Y1 - 1999
N2 - Experimental studies have shown that high pulmonary pressures occurring during ventilation may damage the capillary walls and lead to pulmonary edema. Knowledge of the structural stress distribution within the alveolar septa is a basic first step towards understanding this phenomenon. A two-dimensional alveolar sac model was developed for analysis of stress distribution in septal walls of a saline-filled lung. A parenchymal micrograph was digitized to yield a geometric replica of a typical alveolar sac. Stress concentrations were shown to develop near curved regions, where both tension and compression values may be as high as 20 times that of average stresses. These stresses and the cyclic loading of mechanical ventilation may increase the gaps between the endothelial cells of the capillary walls, and thereby, give rise to pulmonary edema.
AB - Experimental studies have shown that high pulmonary pressures occurring during ventilation may damage the capillary walls and lead to pulmonary edema. Knowledge of the structural stress distribution within the alveolar septa is a basic first step towards understanding this phenomenon. A two-dimensional alveolar sac model was developed for analysis of stress distribution in septal walls of a saline-filled lung. A parenchymal micrograph was digitized to yield a geometric replica of a typical alveolar sac. Stress concentrations were shown to develop near curved regions, where both tension and compression values may be as high as 20 times that of average stresses. These stresses and the cyclic loading of mechanical ventilation may increase the gaps between the endothelial cells of the capillary walls, and thereby, give rise to pulmonary edema.
UR - http://www.scopus.com/inward/record.url?scp=0033322803&partnerID=8YFLogxK
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AN - SCOPUS:0033322803
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 327
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Y2 - 13 October 1999 through 16 October 1999
ER -