Bioluminescent whole-cell biosensor for on-line water toxicity detection

Ronen Almog, Ramiz Daniel, Sharon Yagur-Kroll, Tal Elad, Sahar Melamed, Shimshon Belkin, Yosi Shacham-Diamand

Research output: Contribution to conferencePaperpeer-review

Abstract

We present a novel microbial whole-cell sensing system for biodefense and environmental pollution monitoring. Real time water toxicity monitoring is achieved using genetically engineered E. coli bioluminescent cells which emit light when exposed to toxic materials. The illumination intensity and its time dependence are a function of the toxicants dose and type. The bacteria are immobilized in a disposable PDMS biochip that provides live cell maintenance and micro fluidics channels for sample injection. Several bacteria strains have been developed, generating a unique response signature for different toxins.

Original languageEnglish
Pages597-599
Number of pages3
StatePublished - 2008
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: 12 Oct 200816 Oct 2008

Conference

Conference12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
Country/TerritoryUnited States
CitySan Diego, CA
Period12/10/0816/10/08

Keywords

  • Bioluminescence
  • Environmental monitoring
  • Genetically engineered bacteria
  • Whole-cell biosensors

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