TY - JOUR
T1 - Biology of Chronic Lymphocytic Leukemia in Different Microenvironments. Clinical and Therapeutic Implications.
AU - Herishanu, Yair
AU - Katz, Ben Zion
AU - Lipsky, Andrew
AU - Wiestner, Adrian
N1 - Funding Information:
Research Support: A.W. is supported by the Intramural Research Program of the National, Heart, Lung and Blood Institute , NIH .
PY - 2013/4
Y1 - 2013/4
N2 - Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature monoclonal B cells in peripheral blood, bone marrow, spleen, and lymph nodes. The trafficking, survival, and proliferation of CLL cells is tightly regulated by the surrounding tissue microenvironment and is mediated by antigenic stimulation, close interaction with various accessory cells and exposure to different cytokines, chemokines, and extracellular matrix components. In the last decade there have been major advances in the understanding of the reciprocal interactions between CLL cells and the various microenvironmental compartments. This article discusses the role of the microenvironment in the context of efforts to develop novel therapeutics that target the biology of CLL.
AB - Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature monoclonal B cells in peripheral blood, bone marrow, spleen, and lymph nodes. The trafficking, survival, and proliferation of CLL cells is tightly regulated by the surrounding tissue microenvironment and is mediated by antigenic stimulation, close interaction with various accessory cells and exposure to different cytokines, chemokines, and extracellular matrix components. In the last decade there have been major advances in the understanding of the reciprocal interactions between CLL cells and the various microenvironmental compartments. This article discusses the role of the microenvironment in the context of efforts to develop novel therapeutics that target the biology of CLL.
KW - B-cell receptor signaling
KW - Chronic lymphocytic leukemia
KW - Microenvironment
KW - Targeted therapy
UR - http://www.scopus.com/inward/record.url?scp=84875802229&partnerID=8YFLogxK
U2 - 10.1016/j.hoc.2013.01.002
DO - 10.1016/j.hoc.2013.01.002
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AN - SCOPUS:84875802229
VL - 27
SP - 173
EP - 206
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
SN - 0889-8588
IS - 2
ER -