Biology of Chronic Lymphocytic Leukemia in Different Microenvironments. Clinical and Therapeutic Implications.

Yair Herishanu, Ben Zion Katz, Andrew Lipsky, Adrian Wiestner

Research output: Contribution to journalReview articlepeer-review

Abstract

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature monoclonal B cells in peripheral blood, bone marrow, spleen, and lymph nodes. The trafficking, survival, and proliferation of CLL cells is tightly regulated by the surrounding tissue microenvironment and is mediated by antigenic stimulation, close interaction with various accessory cells and exposure to different cytokines, chemokines, and extracellular matrix components. In the last decade there have been major advances in the understanding of the reciprocal interactions between CLL cells and the various microenvironmental compartments. This article discusses the role of the microenvironment in the context of efforts to develop novel therapeutics that target the biology of CLL.

Original languageEnglish
Pages (from-to)173-206
Number of pages34
JournalHematology/Oncology Clinics of North America
Volume27
Issue number2
DOIs
StatePublished - Apr 2013
Externally publishedYes

Keywords

  • B-cell receptor signaling
  • Chronic lymphocytic leukemia
  • Microenvironment
  • Targeted therapy

Fingerprint

Dive into the research topics of 'Biology of Chronic Lymphocytic Leukemia in Different Microenvironments. Clinical and Therapeutic Implications.'. Together they form a unique fingerprint.

Cite this