TY - JOUR
T1 - Biology-Inspired Supramolecular Peptide Systems
AU - Lampel, Ayala
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/6/11
Y1 - 2020/6/11
N2 - Supramolecular living matter is remarkably complex in composition and structure and often exists far from equilibrium. The biological manufacturing process involves compartmentalization and confinement, supramolecular templating, and cascades of enzymatic reactions to produce structures at a variety of size scales that are formed in highly heterogeneous environments. In contrast, laboratory-based materials are typically formed as single- or bi-component systems in homogeneous, chemically “sterile” environments, therefore destined to be significantly less complex. Fortunately, over the last two decades, major developments in supramolecular chemistry and systems chemistry have made the construction of life-like peptide-based materials increasingly attainable. Peptide structures can now be designed with controlled hierarchy and symmetry, as ordered or disordered or dynamic assemblies, for the generation of complex responsive materials that adapt their properties in response to chemical or physical stimuli. In this Perspective, we highlight these recent efforts by focusing on the underlying molecular design and discuss where the field is heading.
AB - Supramolecular living matter is remarkably complex in composition and structure and often exists far from equilibrium. The biological manufacturing process involves compartmentalization and confinement, supramolecular templating, and cascades of enzymatic reactions to produce structures at a variety of size scales that are formed in highly heterogeneous environments. In contrast, laboratory-based materials are typically formed as single- or bi-component systems in homogeneous, chemically “sterile” environments, therefore destined to be significantly less complex. Fortunately, over the last two decades, major developments in supramolecular chemistry and systems chemistry have made the construction of life-like peptide-based materials increasingly attainable. Peptide structures can now be designed with controlled hierarchy and symmetry, as ordered or disordered or dynamic assemblies, for the generation of complex responsive materials that adapt their properties in response to chemical or physical stimuli. In this Perspective, we highlight these recent efforts by focusing on the underlying molecular design and discuss where the field is heading.
KW - SDG3: Good health and well-being
KW - life-like materials
KW - liquid-liquid phase separation
KW - peptide self-assembly
KW - supramolecular materials
KW - systems chemistry
UR - http://www.scopus.com/inward/record.url?scp=85085918060&partnerID=8YFLogxK
U2 - 10.1016/j.chempr.2020.03.005
DO - 10.1016/j.chempr.2020.03.005
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AN - SCOPUS:85085918060
VL - 6
SP - 1222
EP - 1236
JO - Chem
JF - Chem
SN - 2451-9294
IS - 6
ER -