Biological therapy prior to repeat ileocolic resection in Crohn’s disease can reduce the postoperative complication rate

N. Horesh, M. R. Freund, Z. Garoufalia, R. Gefen, D. Zhang, T. Smith, S. H. Emile, S. D. Wexner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: The aim of this study was to assess the effect of preoperative biologic therapy on the surgical outcome of Crohn’s disease (CD) patients undergoing repeat ileocolic resection. Methods: This was a retrospective analysis of all CD patients who underwent repeat ileocolic resection at Cleveland Clinic Florida between January 2011 and April 2021. Patients were divided into two groups: treatment biologic therapy prior to surgery and controls. Results: Sixty-five patients (31males, median age 54 [range 23–82] years) were included in the study. Twenty nine (44.6%) were treated with biologic therapy prior to repeat ileocolic resection. No demographic differences were found between the biologic therapy and control groups. In addition, no differences were found in mean time from index ileocolic resection (p = 0.9), indication for surgery (p = 0.11), and preoperative albumin (p = 0.69). The majority of patients (57; 87.7%) were operated on laparoscopically, and mean overall operation time was 225 (SD 49.27) min. Overall, the postoperative complication rate was 43.1% (28 patients) and median length of stay was 5 (range 2–21) days. Postoperative complications were more common in the control group, compared to the biologic therapy group (55.6 vs 27.5%; p = 0.04). Conversion rate (35.7 vs 20.7%; p = 0.24), operation time (223 vs 219 min; p = 0.75), length of stay (5.2 vs 5.9 days; p = 0.4), and readmission (16.6 vs 11.1%; p = 0.72) were similar between the two groups. Multivariate analysis of risk factors for postoperative complications showed that biologic treatment was correlated with a lower risk (HR −0.28, CI 95% −0.5596 to −0.01898, p = 0.03). Conclusions: Patients treated with biologic therapy for CD who underwent repeat ileocolic resection had fewer postoperative complications.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalTechniques in Coloproctology
Issue number4
StatePublished - Apr 2023
Externally publishedYes


  • Crohn’s disease
  • Postoperative complications
  • Repeat ileocolic resection


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