TY - JOUR
T1 - Biological exposure metrics of beryllium-exposed dental technicians
AU - Stark, Moshe
AU - Lerman, Yehuda
AU - Kapel, Arik
AU - Pardo, Asher
AU - Schwarz, Yehuda
AU - Newman, Lee
AU - Maier, Lisa
AU - Fireman, Elizabeth
N1 - Funding Information:
The research was funded partly the USA-Israel Bi-National Science Foundation. This work was performed in partial fulfillment of the requirements for a PhD degree of Moshe Stark, Sackler Faculty of Medicine, Tel Aviv University, Israel. For comments and further information, address correspondence to Elizabeth Fireman, PhD, Institute of Pulmonary and Allergic Diseases, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel. E-mail: [email protected]
PY - 2014
Y1 - 2014
N2 - Beryllium is commonly used in the dental industry. This study investigates the association between particle size and shape in induced sputum (IS) with beryllium exposure and oxidative stress in 83 dental technicians. Particle size and shape were defined by laser and video, whereas beryllium exposure data came from self-reports and beryllium lymphocyte proliferation test (BeLPT) results. Heme oxygenase-1 (HO1) gene expression in IS was evaluated by quantitative polymerase chain reaction. A high content of particles (92%) in IS >5 μ in size is correlated to a positive BeLPT risk (odds ratio [OR]=3.4, 95% confidence interval [CI]: 0.9-13). Use of masks, hoods, and type of exposure yielded differences in the transparency of IS particles (gray level) and modulate HO1 levels. These results indicate that parameters of size and shape of particles in IS are sensitive to workplace hygiene, affect the level of oxidative stress, and may be potential markers for monitoring hazardous dust exposures.
AB - Beryllium is commonly used in the dental industry. This study investigates the association between particle size and shape in induced sputum (IS) with beryllium exposure and oxidative stress in 83 dental technicians. Particle size and shape were defined by laser and video, whereas beryllium exposure data came from self-reports and beryllium lymphocyte proliferation test (BeLPT) results. Heme oxygenase-1 (HO1) gene expression in IS was evaluated by quantitative polymerase chain reaction. A high content of particles (92%) in IS >5 μ in size is correlated to a positive BeLPT risk (odds ratio [OR]=3.4, 95% confidence interval [CI]: 0.9-13). Use of masks, hoods, and type of exposure yielded differences in the transparency of IS particles (gray level) and modulate HO1 levels. These results indicate that parameters of size and shape of particles in IS are sensitive to workplace hygiene, affect the level of oxidative stress, and may be potential markers for monitoring hazardous dust exposures.
KW - Beryllium
KW - Bio monitoring
KW - Dental technician
KW - Occupational exposure
KW - Particles exposure
KW - Sputum induction
UR - http://www.scopus.com/inward/record.url?scp=84891696686&partnerID=8YFLogxK
U2 - 10.1080/19338244.2012.744736
DO - 10.1080/19338244.2012.744736
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AN - SCOPUS:84891696686
SN - 1933-8244
VL - 69
SP - 89
EP - 99
JO - Archives of Environmental and Occupational Health
JF - Archives of Environmental and Occupational Health
IS - 2
ER -