TY - JOUR
T1 - Biologic therapy for autoimmune diseases
T2 - An update
AU - Rosman, Ziv
AU - Shoenfeld, Yehuda
AU - Zandman-Goddard, Gisele
PY - 2013/4/4
Y1 - 2013/4/4
N2 - Biologic therapies for rheumatologic diseases, which are targeted at molecules involved in the mechanisms of the immune system, provide an alternative to the existing treatment methods of disease-modifying anti-rheumatic drugs and other immunosuppressive medications. However, the current drawbacks of biologic therapies, including the inconvenience of intravenous administration, the high costs of these drugs, and the adverse events associated with them, prevent their wide use as first-line medications. This review provides an update of the recent literature on the new biologic therapies available. The review concentrates on nine drugs: tocilizumab, rituximab, ofatumumab, belimumab, epratuzumab, abatacept, golimumab, certolizumab, and sifalimumab, which are used as therapies for rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, systemic sclerosis, or vasculitis.
AB - Biologic therapies for rheumatologic diseases, which are targeted at molecules involved in the mechanisms of the immune system, provide an alternative to the existing treatment methods of disease-modifying anti-rheumatic drugs and other immunosuppressive medications. However, the current drawbacks of biologic therapies, including the inconvenience of intravenous administration, the high costs of these drugs, and the adverse events associated with them, prevent their wide use as first-line medications. This review provides an update of the recent literature on the new biologic therapies available. The review concentrates on nine drugs: tocilizumab, rituximab, ofatumumab, belimumab, epratuzumab, abatacept, golimumab, certolizumab, and sifalimumab, which are used as therapies for rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, systemic sclerosis, or vasculitis.
KW - Anti-TNF
KW - Autoimmune diseases
KW - B cell depletion
KW - Biologics
KW - Rheumatoid arthritis
KW - Spondyloarthritis
KW - Systemic lupus erythematosus
KW - Systemic sclerosis
KW - Vasculitis
UR - http://www.scopus.com/inward/record.url?scp=84875687447&partnerID=8YFLogxK
U2 - 10.1186/1741-7015-11-88
DO - 10.1186/1741-7015-11-88
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AN - SCOPUS:84875687447
SN - 1741-7015
VL - 11
JO - BMC Medicine
JF - BMC Medicine
IS - 1
M1 - 88
ER -