Biologic modulation of chemotherapy in patients with hepatic colorectal metastases: The role of anti-VEGF and anti-EGFR antibodies

In the treatment of metastatic colorectal cancer, the subset of patients with liver-only metastases shows the greatest promise for prolonged survival and cure. Advances in surgery and medical treatment have encouraged multimodality treatment strategies and therefore require a true multidisciplinary approach. The current standard of care includes peri-operative chemotherapy and surgery. The new era of biologically targeted therapy requires an in-depth look at the possible efficacy and risks of adding these agents to the treatment protocol. © 2010 Wiley-Liss, Inc.