Bioengineering research of chronic wounds: a multidisciplinary study approach

Amit Gefen (Editor)

Research output: Book/ReportBookpeer-review


Pressure-related chronic wounds are an important health concern that affects millions of patients and accumulates billions in annual costs. These wounds may occur when soft tissues are mechanically compressed between bony prominences and a supporting surface. This book gives a complete and quantitative explanation of the mechanobiology which causes chronic wounds. The reviews give an overall picture on all length scales of the phenomenon, starting from musculoskeletal biomechanics to the modeling of soft tissues and their interaction with bones. At the microscopic levels, it thoroughly reviews experiments and modeling of cellular forces and molecular processes that occur during injury and healing, including the integrity of living cells subjected to sustained mechanical forces and deformations. The results allow a complete picture of the tolerance of human tissues to sustained loads, and an understanding of the risk for onset of chronic wounds. Hence, this book is also valuable for all professionals involved in the prevention and treatment of chronic wounds.
Original languageEnglish
Place of PublicationBerlin; London
Number of pages447
ISBN (Electronic)1282509640, 3642005349, 9786612509643
ISBN (Print)3642005330, 9783642005336
StatePublished - 2009

Publication series

NameStudies in mechanobiology, tissue engineering and biomaterials

ULI Keywords

  • uli
  • Bedsores
  • Biomechanics
  • Wounds and injuries -- Prevention
  • Wounds and injuries -- Treatment
  • Bed-sores
  • Decubiti
  • Decubitus ulcers
  • Pressure sores
  • Pressure ulcers
  • Biological mechanics
  • Mechanical properties of biological structures


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