Biodegradable, Biocompatible, and Implantable Multifunctional Sensing Platform for Cardiac Monitoring

Rawan Omar, Walaa Saliba, Muhammad Khatib, Youbin Zheng, Calvin Pieters, Hadas Oved, Eric Silberman, Orr Zohar, Zhipeng Hu, Viki Kloper, Yoav Y. Broza, Tal Dvir, Alon Grinberg Dana, Yan Wang*, Hossam Haick*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac monitoring after heart surgeries is crucial for health maintenance and detecting postoperative complications early. However, current methods like rigid implants have limitations, as they require performing second complex surgeries for removal, increasing infection and inflammation risks, thus prompting research for improved sensing monitoring technologies. Herein, we introduce a nanosensor platform that is biodegradable, biocompatible, and integrated with multifunctions, suitable for use as implants for cardiac monitoring. The device has two electrochemical biosensors for sensing lactic acid and pH as well as a pressure sensor and a chemiresistor array for detecting volatile organic compounds. Its biocompatibility with myocytes has been tested in vitro, and its biodegradability and sensing function have been proven with ex vivo experiments using a three-dimensional (3D)-printed heart model and 3D-printed cardiac tissue patches. Moreover, an artificial intelligence-based predictive model was designed to fuse sensor data for more precise health assessment, making it a suitable candidate for clinical use. This sensing platform promises impactful applications in the realm of cardiac patient care, laying the foundation for advanced life-saving developments.

Original languageEnglish
Pages (from-to)126-138
Number of pages13
JournalACS Sensors
Volume9
Issue number1
DOIs
StatePublished - 26 Jan 2024

Funding

FundersFunder number
Bill and Melinda Gates FoundationOPP1109493
Horizon 2020 Framework Programme
Servier

    Keywords

    • artificial intelligence
    • biodegradable
    • cardiac monitoring
    • health monitoring
    • implantable sensor
    • multifunctional

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