Biochemical corroboration of endothelial involvement in severe preeclampsia

Steven A. Friedman, Eyal Schiff, Jef J. Emeis, Gustaaf A. Dekker, Baha M. Sibai

Research output: Contribution to journalArticlepeer-review

Abstract

This prospective, nested, case-control study investigated whether elevated plasma cellular fibronectin concentrations previously reported in preeclamptic women likely reflect endothelial dysfunction. In addition to higher maternal plasma concentrations of cellular fibronectin, we found higher levels of von Willebrand factor, tissue plasminogen activator, and plasminogen activator inhibitor-1 in maternal plasma, providing biochemical corroboration of endothelial dysfunction in severe preeclampsia.

Original languageEnglish
Pages (from-to)202-203
Number of pages2
JournalAmerican Journal of Obstetrics and Gynecology
Volume172
Issue number1 PART 1
DOIs
StatePublished - Jan 1995

Keywords

  • Preeclampsia
  • cellular fibronectin
  • endothelium
  • plasminogen activator inhibitor-1
  • tissue plasminogen activator
  • von Willebrand factor

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