Biochemical corroboration of endothelial involvement in severe preeclampsia

Steven A. Friedman*, Eyal Schiff, Jef J. Emeis, Gustaaf A. Dekker, Baha M. Sibai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

132 Scopus citations


This prospective, nested, case-control study investigated whether elevated plasma cellular fibronectin concentrations previously reported in preeclamptic women likely reflect endothelial dysfunction. In addition to higher maternal plasma concentrations of cellular fibronectin, we found higher levels of von Willebrand factor, tissue plasminogen activator, and plasminogen activator inhibitor-1 in maternal plasma, providing biochemical corroboration of endothelial dysfunction in severe preeclampsia.

Original languageEnglish
Pages (from-to)202-203
Number of pages2
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1 PART 1
StatePublished - Jan 1995


  • Preeclampsia
  • cellular fibronectin
  • endothelium
  • plasminogen activator inhibitor-1
  • tissue plasminogen activator
  • von Willebrand factor


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