TY - JOUR
T1 - Biochemical corroboration of endothelial involvement in severe preeclampsia
AU - Friedman, Steven A.
AU - Schiff, Eyal
AU - Emeis, Jef J.
AU - Dekker, Gustaaf A.
AU - Sibai, Baha M.
PY - 1995/1
Y1 - 1995/1
N2 - This prospective, nested, case-control study investigated whether elevated plasma cellular fibronectin concentrations previously reported in preeclamptic women likely reflect endothelial dysfunction. In addition to higher maternal plasma concentrations of cellular fibronectin, we found higher levels of von Willebrand factor, tissue plasminogen activator, and plasminogen activator inhibitor-1 in maternal plasma, providing biochemical corroboration of endothelial dysfunction in severe preeclampsia.
AB - This prospective, nested, case-control study investigated whether elevated plasma cellular fibronectin concentrations previously reported in preeclamptic women likely reflect endothelial dysfunction. In addition to higher maternal plasma concentrations of cellular fibronectin, we found higher levels of von Willebrand factor, tissue plasminogen activator, and plasminogen activator inhibitor-1 in maternal plasma, providing biochemical corroboration of endothelial dysfunction in severe preeclampsia.
KW - Preeclampsia
KW - cellular fibronectin
KW - endothelium
KW - plasminogen activator inhibitor-1
KW - tissue plasminogen activator
KW - von Willebrand factor
UR - http://www.scopus.com/inward/record.url?scp=0028939237&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(95)90113-2
DO - 10.1016/0002-9378(95)90113-2
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C2 - 7847535
AN - SCOPUS:0028939237
SN - 0002-9378
VL - 172
SP - 202
EP - 203
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 1 PART 1
ER -