Bioavailability of a pediatric amlodipine suspension

Dorothy A. Lyszkiewicz; Zina Levichek; Eran Kozer; Yaron Yagev; Myla Moretti; Marjie Hard; Gideon Koren

doi:10.1007/s00467-003-1088-2

Bioavailability of a pediatric amlodipine suspension

Dorothy A. Lyszkiewicz, Zina Levichek, Eran Kozer, Yaron Yagev, Myla Moretti, Marjie Hard, Gideon Koren^*

^*Corresponding author for this work

University of Toronto

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Currently, a suspension of crushed tablets of amlodidpine is widely used in children with hypertension without knowledge of its bioavailability. A comparative bioavailability study of a tablet and suspension formulation of amlodipine was completed in 20 healthy adult volunteers. Bioequivalence of the suspension was not different from the tablets. These results support the use of the suspension in children who cannot take the tablet.

Original language	English
Pages (from-to)	675-678
Number of pages	4
Journal	Pediatric Nephrology
Volume	18
Issue number	7
DOIs	https://doi.org/10.1007/s00467-003-1088-2
State	Published - 1 Jul 2003
Externally published	Yes

Keywords

Amlodipine
Bioavailability
Bioequivalence
Pediatric formulation
Stability
Suspension

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10.1007/s00467-003-1088-2

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AU - Moretti, Myla

AU - Hard, Marjie

AU - Koren, Gideon

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AB - Currently, a suspension of crushed tablets of amlodidpine is widely used in children with hypertension without knowledge of its bioavailability. A comparative bioavailability study of a tablet and suspension formulation of amlodipine was completed in 20 healthy adult volunteers. Bioequivalence of the suspension was not different from the tablets. These results support the use of the suspension in children who cannot take the tablet.

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KW - Bioequivalence

KW - Pediatric formulation

KW - Stability

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Bioavailability of a pediatric amlodipine suspension

Abstract

Keywords

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