TY - JOUR
T1 - Biliary and systemic effects of fatty acid bile acid conjugates
AU - Konikoff, Fred M.
AU - Leikin-Frenkel, Alicia
AU - Goldiner, Ilana
AU - Michowitz, Moshe
AU - Brezowski, Eli
AU - Harats, Dror
AU - Gilat, Tuvia
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Background: Fatty acid bile acid conjugates (FABACs) are novel synthetic molecules that solubilize cholesterol, prevent cholesterol crystal and gallstone formation, and dissolve pre-existing gallstones in mice. They are thus potential agents for gallstone prevention and treatment. The available knowledge concerning their biliary, systemic or possible toxic effects is, however, incomplete. Aim: To obtain information regarding biliary and systemic effects of FABACs. Methods: Hamsters, rats and mice were administered C20-FABAC intragastrically, and serum and bile chemistries, organ histology, animal wellbeing, and survival were monitored. Results: FABAC feeding (150 mg/kg/day) caused no adverse effects in any of the animal species studied. FABAC did not influence biliary cholesterol, phospholipid, or bile-salt concentrations in mice. In hamsters, biliary cholesterol concentration decreased slightly, but effects on phospholipids and bile salts were inconsistent. In some mouse strains, FABAC supplementation increased transaminases slightly. In hamsters and rats, transaminases were mainly unaffected or even decreased. Serum alkaline phosphatase, creatinine, albumin and glucose were generally unaffected by FABAC feeding. No gross or histopathological differences between controls and FABAC-fed animals were noted in any of the organs investigated. Conclusions: C20-FABAC given at a pharmacological dose is safe and devoid of any significant toxic effects in three different animal species.
AB - Background: Fatty acid bile acid conjugates (FABACs) are novel synthetic molecules that solubilize cholesterol, prevent cholesterol crystal and gallstone formation, and dissolve pre-existing gallstones in mice. They are thus potential agents for gallstone prevention and treatment. The available knowledge concerning their biliary, systemic or possible toxic effects is, however, incomplete. Aim: To obtain information regarding biliary and systemic effects of FABACs. Methods: Hamsters, rats and mice were administered C20-FABAC intragastrically, and serum and bile chemistries, organ histology, animal wellbeing, and survival were monitored. Results: FABAC feeding (150 mg/kg/day) caused no adverse effects in any of the animal species studied. FABAC did not influence biliary cholesterol, phospholipid, or bile-salt concentrations in mice. In hamsters, biliary cholesterol concentration decreased slightly, but effects on phospholipids and bile salts were inconsistent. In some mouse strains, FABAC supplementation increased transaminases slightly. In hamsters and rats, transaminases were mainly unaffected or even decreased. Serum alkaline phosphatase, creatinine, albumin and glucose were generally unaffected by FABAC feeding. No gross or histopathological differences between controls and FABAC-fed animals were noted in any of the organs investigated. Conclusions: C20-FABAC given at a pharmacological dose is safe and devoid of any significant toxic effects in three different animal species.
KW - Bile
KW - Bile acids
KW - Cholesterol
KW - Fatty acid bile acid conjugates (FABACs)
KW - Gallstones
KW - Phospholipids
UR - http://www.scopus.com/inward/record.url?scp=0038797812&partnerID=8YFLogxK
U2 - 10.1097/00042737-200306000-00012
DO - 10.1097/00042737-200306000-00012
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AN - SCOPUS:0038797812
SN - 0954-691X
VL - 15
SP - 649
EP - 655
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
IS - 6
ER -