TY - JOUR
T1 - Bile Composition and Bile Acid Pool Size
T2 - Comparison After Truncal, Selective, and Highly Selective Vagotomy
AU - Witz, Misha
AU - Schneider, Ayala
AU - Novis, Bentley
AU - Engelberg, Moshe
AU - Dinbar, Alex
PY - 1985/11
Y1 - 1985/11
N2 - We studied biliary lipid composition and bile acid pool size in 29 patients surgically treated for duodenal ulcer. Fourteen were examined both before and after surgery, the rest postsurgically only. They were divided into three groups according to type of vagotomy. With duodenal fluid obtained via nasogastric tube, we determined bile acid pool size, bile concentrations, and lithogenic index. We found no significant differences in bile composition and bile acid pool size among the three types of vagotomy, postsurgically. However, patients studied before surgery, compared with the entire post-vagotomy group, had a significant increase in relative cholesterol content and lithogenic index, most pronounced in the truncal vagotomy group. Bile acid pool size was also increased postsurgically. Vagotomy may predispose to gallstone development by increasing the bile's relative cholesterol concentration and thus the lithogenic index. However, the slightly expanded bile acid pool size may improve cholesterol solubility in certain patients.
AB - We studied biliary lipid composition and bile acid pool size in 29 patients surgically treated for duodenal ulcer. Fourteen were examined both before and after surgery, the rest postsurgically only. They were divided into three groups according to type of vagotomy. With duodenal fluid obtained via nasogastric tube, we determined bile acid pool size, bile concentrations, and lithogenic index. We found no significant differences in bile composition and bile acid pool size among the three types of vagotomy, postsurgically. However, patients studied before surgery, compared with the entire post-vagotomy group, had a significant increase in relative cholesterol content and lithogenic index, most pronounced in the truncal vagotomy group. Bile acid pool size was also increased postsurgically. Vagotomy may predispose to gallstone development by increasing the bile's relative cholesterol concentration and thus the lithogenic index. However, the slightly expanded bile acid pool size may improve cholesterol solubility in certain patients.
UR - http://www.scopus.com/inward/record.url?scp=0022196452&partnerID=8YFLogxK
U2 - 10.1001/archsurg.1985.01390350086018
DO - 10.1001/archsurg.1985.01390350086018
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AN - SCOPUS:0022196452
SN - 0004-0010
VL - 120
SP - 1306
EP - 1309
JO - Archives of Surgery
JF - Archives of Surgery
IS - 11
ER -