TY - JOUR
T1 - Bilateral retinal vein occlusion associated with 5,10- methylenetetrahydrofolate reductase mutation
AU - Loewenstein, A.
AU - Winder, A.
AU - Goldstein, M.
AU - Lazar, M.
AU - Eldor, A.
PY - 1997
Y1 - 1997
N2 - PURPOSE: To report on the occurrence of 5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency, known to cause mild to moderate hyperhomocystinemia and increased risk of vascular occlusive disease, in a young patient with bilateral central retinal vein occlusion. METHODS: A 25- year-old man was initially examined with central retinal vein occlusion in the right eye, followed 4 months later by a central retinal vein occlusion in the left eye. Studies for risk factors predisposing to thrombosis were performed. RESULTS: Hematologic studies failed to detect any pathology. However, the patient was found to be homozygous for 677C-T mutation in MTHFR enzyme. CONCLUSION: Central retinal vein occlusion may be associated with a mutation in MTHFR.
AB - PURPOSE: To report on the occurrence of 5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency, known to cause mild to moderate hyperhomocystinemia and increased risk of vascular occlusive disease, in a young patient with bilateral central retinal vein occlusion. METHODS: A 25- year-old man was initially examined with central retinal vein occlusion in the right eye, followed 4 months later by a central retinal vein occlusion in the left eye. Studies for risk factors predisposing to thrombosis were performed. RESULTS: Hematologic studies failed to detect any pathology. However, the patient was found to be homozygous for 677C-T mutation in MTHFR enzyme. CONCLUSION: Central retinal vein occlusion may be associated with a mutation in MTHFR.
UR - http://www.scopus.com/inward/record.url?scp=0030862371&partnerID=8YFLogxK
U2 - 10.1016/S0002-9394(14)71703-9
DO - 10.1016/S0002-9394(14)71703-9
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C2 - 9402832
AN - SCOPUS:0030862371
SN - 0002-9394
VL - 124
SP - 840
EP - 841
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 6
ER -