TY - JOUR
T1 - Bilateral effect of unilateral dexamethasone intravitreal implant in a case of noninfectious uveitic macular edema and vitritis
AU - Habot-Wilner, Zohar
AU - Sorkin, Nir
AU - Goldenberg, Dafna
AU - Goldstein, Michaella
N1 - Publisher Copyright:
Copyright © by Ophthalmic Communications Society, Inc.
PY - 2015/4/6
Y1 - 2015/4/6
N2 - Purpose: To describe a bilateral therapeutic effect of the 0.7-mg dexamethasone drug delivery system injected in 1 eye of a patient with bilateral, noninfectious uveitic macular edema and vitritis. Methods: Interventional case report. Results: A 26-year-old woman had vitritis and macular edema in both eyes and received a dexamethasone drug delivery system injection to the right eye. Best-corrected visual acuity, clinical examination, and Heidelberg Spectralis spectral domain optical coherence tomography were performed at baseline and during follow-up visits. Follow-up time was 24 months. Vitritis and macular edema completely resolved in both eyes with bilateral improvement in visual acuity. Treatment effect enabled systemic immunosuppressive treatment to be lowered, and the effect lasted for 24 months. Conclusion: Unilateral dexamethasone drug delivery system injectionmight have a bilateral therapeutic effect in uveitic eyes. This observation may be related to the compromised blood- retina barrier in eyes with uveitis. Further studies are warranted to assess this effect.
AB - Purpose: To describe a bilateral therapeutic effect of the 0.7-mg dexamethasone drug delivery system injected in 1 eye of a patient with bilateral, noninfectious uveitic macular edema and vitritis. Methods: Interventional case report. Results: A 26-year-old woman had vitritis and macular edema in both eyes and received a dexamethasone drug delivery system injection to the right eye. Best-corrected visual acuity, clinical examination, and Heidelberg Spectralis spectral domain optical coherence tomography were performed at baseline and during follow-up visits. Follow-up time was 24 months. Vitritis and macular edema completely resolved in both eyes with bilateral improvement in visual acuity. Treatment effect enabled systemic immunosuppressive treatment to be lowered, and the effect lasted for 24 months. Conclusion: Unilateral dexamethasone drug delivery system injectionmight have a bilateral therapeutic effect in uveitic eyes. This observation may be related to the compromised blood- retina barrier in eyes with uveitis. Further studies are warranted to assess this effect.
KW - dexamethasone drug delivery system
KW - dexamethasone intravitreal implant
KW - uveitic macular edema
KW - uveitis
KW - vitritis
UR - https://www.scopus.com/pages/publications/84926306079
U2 - 10.1097/ICB.0000000000000122
DO - 10.1097/ICB.0000000000000122
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C2 - 25462131
AN - SCOPUS:84926306079
SN - 1935-1089
VL - 9
SP - 151
EP - 153
JO - Retinal Cases and Brief Reports
JF - Retinal Cases and Brief Reports
IS - 2
ER -