Bilateral effect of unilateral dexamethasone intravitreal implant in a case of noninfectious uveitic macular edema and vitritis

Zohar Habot-Wilner*, Nir Sorkin, Dafna Goldenberg, Michaella Goldstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To describe a bilateral therapeutic effect of the 0.7-mg dexamethasone drug delivery system injected in 1 eye of a patient with bilateral, noninfectious uveitic macular edema and vitritis. Methods: Interventional case report. Results: A 26-year-old woman had vitritis and macular edema in both eyes and received a dexamethasone drug delivery system injection to the right eye. Best-corrected visual acuity, clinical examination, and Heidelberg Spectralis spectral domain optical coherence tomography were performed at baseline and during follow-up visits. Follow-up time was 24 months. Vitritis and macular edema completely resolved in both eyes with bilateral improvement in visual acuity. Treatment effect enabled systemic immunosuppressive treatment to be lowered, and the effect lasted for 24 months. Conclusion: Unilateral dexamethasone drug delivery system injectionmight have a bilateral therapeutic effect in uveitic eyes. This observation may be related to the compromised blood- retina barrier in eyes with uveitis. Further studies are warranted to assess this effect.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalRetinal Cases and Brief Reports
Volume9
Issue number2
DOIs
StatePublished - 6 Apr 2015
Externally publishedYes

Keywords

  • dexamethasone drug delivery system
  • dexamethasone intravitreal implant
  • uveitic macular edema
  • uveitis
  • vitritis

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