Bifunctional Carbon-Dot-WS2 Nanorods for Photothermal Therapy and Cell Imaging

Sukhendu Nandi, Susanta Kumar Bhunia, Leila Zeiri, Maayan Pour, Iftach Nachman, Daniel Raichman, Jean Paul Moshe Lellouche, Raz Jelinek

Research output: Contribution to journalArticlepeer-review

Abstract

Multifunctional nanoparticles have attracted significant interest as biomedical vehicles, combining diagnostic, imaging, and therapeutic properties. We describe herein the construction of new nanoparticle conjugates comprising WS2 nanorods (NRs) coupled to fluorescent carbon dots (C-dots). We show that the WS2-C-dot hybrids integrate the unique physical properties of the two species, specifically the photothermal activity of the WS2 NRs upon irradiation with near-infrared (NIR) light and the excitation-dependent luminescence emission of the C-dots. The WS2-C-dot NRs have been shown to be non-cytotoxic and have been successfully employed for multicolour cell imaging and targeted cell killing under NIR irradiation, pointing to their potential utilization as effective therapeutic vehicles.

Original languageEnglish
Pages (from-to)963-969
Number of pages7
JournalChemistry - A European Journal
Volume23
Issue number4
DOIs
StatePublished - 18 Jan 2017

Keywords

  • carbon dots
  • cell imaging
  • fluorescent probes
  • multicolour fluorescence imaging
  • nanostructures
  • photothermal therapy

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