Bidirectional concentration-dependent effects of tumor necrosis factor alpha in Shigella dysenteriae-related seizures

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Abstract

We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-α) was proconvulsive in this respect. The present study shows that TNF-α, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-α may play a protective role in neurologic complications of S. dysenteriae infection.

Original languageEnglish
Pages (from-to)2288-2291
Number of pages4
JournalInfection and Immunity
Volume71
Issue number4
DOIs
StatePublished - 1 Apr 2003

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