@article{98b20d15ebda4b57868d8d5613d3d579,
title = "Biased hosting of intronic microRNA genes",
abstract = "Motivation: MicroRNAs (miRNAs) are involved in an abundant class of post-transcriptional regulation activated through binding to the 3'-untranslated region (UTR) of mRNAs. The current wealth of mammalian miRNA genes results mostly from genomic duplication events. Many of these events are located within introns of transcriptional units. In order to better understand the genomic expansion of miRNA genes, we investigated the distribution of intronic miRNAs. Results: We observe that miRNA genes are hosted within introns of short genes much larger than expected by chance. Implementation: We explore several explanations for this phenomenon and conclude that miRNA integration into short genes might be evolutionary favorable due to interaction with the pre-mRNA splicing mechanism. Contact:
[email protected]. Supplementary information: Supplementary data are available at Bioinformatics online.",
author = "David Golan and Carmit Levy and Brad Friedman and Noam Shomron",
note = "Funding Information: Funding: Work in the NS laboratory is supported by the Chief Scientist Office, Ministry of Health, Israel [3-4876]; Kurz-Lion Foundation; Ori Levi Foundation for Mitochondrial research; Tel Aviv University, Sackler Faculty of Medicine, Schreiber Fellowship.",
year = "2010",
month = feb,
day = "24",
doi = "10.1093/bioinformatics/btq077",
language = "אנגלית",
volume = "26",
pages = "992--995",
journal = "Bioinformatics",
issn = "1367-4803",
publisher = "Oxford University Press",
number = "8",
}