Beyond the symptom: the biology of fatigue

David M. Raizen; Janet Mullington; Christelle Anaclet; Gerard Clarke; Hugo Critchley; Robert Dantzer; Ronald Davis; Kelly L. Drew; Josh Fessel; Patrick M. Fuller; Erin M. Gibson; Mary Harrington; W. Ian Lipkin; Elizabeth B. Klerman; Nancy Klimas; Anthony L. Komaroff; Walter Koroshetz; Lauren Krupp; Anna Kuppuswamy; Julie Lasselin; Laura D. Lewis; Pierre J. Magistretti; Heidi Y. Matos; Christine Miaskowski; Andrew H. Miller; Avindra Nath; Maiken Nedergaard; Mark R. Opp; Marylyn D. Ritchie; Dragana Rogulja; Asya Rolls; John D. Salamone; Clifford Saper; Vicky Whittemore; Glenn Wylie; Jarred Younger; Phyllis C. Zee; H. Craig Heller

doi:10.1093/sleep/zsad069

Beyond the symptom: the biology of fatigue

David M. Raizen, Janet Mullington, Christelle Anaclet, Gerard Clarke, Hugo Critchley, Robert Dantzer, Ronald Davis, Kelly L. Drew, Josh Fessel, Patrick M. Fuller, Erin M. Gibson, Mary Harrington, W. Ian Lipkin, Elizabeth B. Klerman, Nancy Klimas, Anthony L. Komaroff, Walter Koroshetz, Lauren Krupp, Anna Kuppuswamy, Julie LasselinLaura D. Lewis, Pierre J. Magistretti, Heidi Y. Matos, Christine Miaskowski, Andrew H. Miller, Avindra Nath, Maiken Nedergaard, Mark R. Opp, Marylyn D. Ritchie, Dragana Rogulja, Asya Rolls, John D. Salamone, Clifford Saper, Vicky Whittemore^*, Glenn Wylie, Jarred Younger, Phyllis C. Zee, H. Craig Heller

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

A workshop titled “Beyond the Symptom: The Biology of Fatigue” was held virtually September 27–28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.

Original language	English
Journal	Sleep
Volume	46
Issue number	9
DOIs	https://doi.org/10.1093/sleep/zsad069
State	Published - 1 Sep 2023
Externally published	Yes

Funding

Funders	Funder number
American Academy of Sleep Medicine Foundation
New York Stem Cell Foundation
Be Cool Pharmaceutics
AARP Foundation
Otsuka America
National Institute of Neurological Disorders and Stroke
European Biological Rhythms Society
University of Tsukuba
Open Medicine Foundation
Circadian Therapeutics
BrightFocus Foundation
European Research Council
National Sleep Foundation
Wellcome Trust	202346/Z/16, R01AG070135, 202346
U.S. Department of Veterans Affairs	5I01CX000893
National Institute of Child Health and Human Development	U54AI138370-06, W81XWH201076, R01-HD107064
National Center for Complementary and Integrative Health	U19NS128613, R21NS123412, RF1NS110049, W81XXWH221084, R01AT011429, R01AT011439, R01AG064465
U.S. Department of Defense	W81XWH-22-1-0069
National Institute on Drug Abuse	R21-DA052861
National Cancer Institute	R01 CA193522
National Institute of Allergy and Infectious Diseases	R01AI139550
University of Connecticut	R01 NS072337, P01 HL149630, R01 MH112714
National Institute of General Medical Sciences	R01NS126610, P20GM130443, R01-NS114526-02S1, R21CA267135, U01-NS114001, R01-NS099055, R01NS103161, P01HL149630, R15 GM126545, W81XWH2110846
NATIONAL MULTIPLE SCLEROSIS SOCIETY	10.005, RG 4232A1, P01AG011412, R01HD097786, R01HL140580, R01AG059291, W81XWH-19-1-0725, R01AG068579, R01-NS109529
National Institute of Mental Health	R01MH121350
National Heart, Lung, and Blood Institute	R01HL125379, R01NS073613
National Institutes of Health	R01NS122779
National Institute on Aging	U54-AG062322

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10.1093/sleep/zsad069

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Raizen, D. M., Mullington, J., Anaclet, C., Clarke, G., Critchley, H., Dantzer, R., Davis, R., Drew, K. L., Fessel, J., Fuller, P. M., Gibson, E. M., Harrington, M., Lipkin, W. I., Klerman, E. B., Klimas, N., Komaroff, A. L., Koroshetz, W., Krupp, L., Kuppuswamy, A., ... Heller, H. C. (2023). Beyond the symptom: the biology of fatigue. Sleep, 46(9). https://doi.org/10.1093/sleep/zsad069

@article{eabb74b441c54f56ad7384a3489b4207,

title = "Beyond the symptom: the biology of fatigue",

abstract = "A workshop titled “Beyond the Symptom: The Biology of Fatigue” was held virtually September 27–28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.",

author = "Raizen, {David M.} and Janet Mullington and Christelle Anaclet and Gerard Clarke and Hugo Critchley and Robert Dantzer and Ronald Davis and Drew, {Kelly L.} and Josh Fessel and Fuller, {Patrick M.} and Gibson, {Erin M.} and Mary Harrington and Lipkin, {W. Ian} and Klerman, {Elizabeth B.} and Nancy Klimas and Komaroff, {Anthony L.} and Walter Koroshetz and Lauren Krupp and Anna Kuppuswamy and Julie Lasselin and Lewis, {Laura D.} and Magistretti, {Pierre J.} and Matos, {Heidi Y.} and Christine Miaskowski and Miller, {Andrew H.} and Avindra Nath and Maiken Nedergaard and Opp, {Mark R.} and Ritchie, {Marylyn D.} and Dragana Rogulja and Asya Rolls and Salamone, {John D.} and Clifford Saper and Vicky Whittemore and Glenn Wylie and Jarred Younger and Zee, {Phyllis C.} and Heller, {H. Craig}",

year = "2023",

month = sep,

day = "1",

doi = "10.1093/sleep/zsad069",

language = "אנגלית",

volume = "46",

journal = "Sleep",

issn = "0161-8105",

publisher = "Oxford University Press",

number = "9",

}

Raizen, DM, Mullington, J, Anaclet, C, Clarke, G, Critchley, H, Dantzer, R, Davis, R, Drew, KL, Fessel, J, Fuller, PM, Gibson, EM, Harrington, M, Lipkin, WI, Klerman, EB, Klimas, N, Komaroff, AL, Koroshetz, W, Krupp, L, Kuppuswamy, A, Lasselin, J, Lewis, LD, Magistretti, PJ, Matos, HY, Miaskowski, C, Miller, AH, Nath, A, Nedergaard, M, Opp, MR, Ritchie, MD, Rogulja, D, Rolls, A, Salamone, JD, Saper, C, Whittemore, V, Wylie, G, Younger, J, Zee, PC & Heller, HC 2023, 'Beyond the symptom: the biology of fatigue', Sleep, vol. 46, no. 9. https://doi.org/10.1093/sleep/zsad069

TY - JOUR

T1 - Beyond the symptom

T2 - the biology of fatigue

AU - Raizen, David M.

AU - Mullington, Janet

AU - Anaclet, Christelle

AU - Clarke, Gerard

AU - Critchley, Hugo

AU - Dantzer, Robert

AU - Davis, Ronald

AU - Drew, Kelly L.

AU - Fessel, Josh

AU - Fuller, Patrick M.

AU - Gibson, Erin M.

AU - Harrington, Mary

AU - Lipkin, W. Ian

AU - Klerman, Elizabeth B.

AU - Klimas, Nancy

AU - Komaroff, Anthony L.

AU - Koroshetz, Walter

AU - Krupp, Lauren

AU - Kuppuswamy, Anna

AU - Lasselin, Julie

AU - Lewis, Laura D.

AU - Magistretti, Pierre J.

AU - Matos, Heidi Y.

AU - Miaskowski, Christine

AU - Miller, Andrew H.

AU - Nath, Avindra

AU - Nedergaard, Maiken

AU - Opp, Mark R.

AU - Ritchie, Marylyn D.

AU - Rogulja, Dragana

AU - Rolls, Asya

AU - Salamone, John D.

AU - Saper, Clifford

AU - Whittemore, Vicky

AU - Wylie, Glenn

AU - Younger, Jarred

AU - Zee, Phyllis C.

AU - Heller, H. Craig

PY - 2023/9/1

Y1 - 2023/9/1

N2 - A workshop titled “Beyond the Symptom: The Biology of Fatigue” was held virtually September 27–28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.

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Beyond the symptom: the biology of fatigue

Abstract

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