TY - JOUR
T1 - Beyond resistance
T2 - antifungal heteroresistance and antifungal tolerance in fungal pathogens
AU - Yang, Feng
AU - Berman, Judith
N1 - Publisher Copyright:
© 2024 Elsevier Ltd
PY - 2024/4
Y1 - 2024/4
N2 - Fungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures. These responses include heteroresistance and tolerance, terms that are more well-defined for antibacterial drugs, but are also evident in pathogenic fungi. Here, we compare these antifungal responses with similarly named antibacterial responses, and we review recent advances in how we understand the routes by which antifungal heteroresistance and tolerance emerge.
AB - Fungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures. These responses include heteroresistance and tolerance, terms that are more well-defined for antibacterial drugs, but are also evident in pathogenic fungi. Here, we compare these antifungal responses with similarly named antibacterial responses, and we review recent advances in how we understand the routes by which antifungal heteroresistance and tolerance emerge.
UR - http://www.scopus.com/inward/record.url?scp=85185763351&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2024.102439
DO - 10.1016/j.mib.2024.102439
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 38401284
AN - SCOPUS:85185763351
SN - 1369-5274
VL - 78
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
M1 - 102439
ER -