Beyond resistance: antifungal heteroresistance and antifungal tolerance in fungal pathogens

Feng Yang, Judith Berman

Research output: Contribution to journalReview articlepeer-review

Abstract

Fungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures. These responses include heteroresistance and tolerance, terms that are more well-defined for antibacterial drugs, but are also evident in pathogenic fungi. Here, we compare these antifungal responses with similarly named antibacterial responses, and we review recent advances in how we understand the routes by which antifungal heteroresistance and tolerance emerge.

Original languageEnglish
Article number102439
JournalCurrent Opinion in Microbiology
Volume78
DOIs
StatePublished - Apr 2024

Funding

FundersFunder number
Natural Science Foundation of Shanghai Municipality23ZR1449500
Natural Science Foundation of Shanghai Municipality
Horizon 2020 Framework Programme
European Research Council
Horizon 2020951475
Horizon 2020

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