Beta-adrenergic receptors in rat myocardium: Direct detection by a new fluorescent beta-blocker

Eldad Melamed, M. Lahav, Daphne Atlas

Research output: Contribution to journalArticlepeer-review

Abstract

A new fluorescent β-blocker, 9-amino-acridin propranolol (9-AAP), was administered i.v. to rats. Multiple fluorescent 9-AAP binding sites were observed on cardiac muscle cells in frozen sections. Intensity and density of cardiac 9-AAP fluorescence were markedly reduced following pretreatment with (±)- and (-)-propranolol but not with (+)-propranolol. Our findings suggest that 9-AAP may label β-adrenergic receptor sites in rat myocardium.

Original languageEnglish
Pages (from-to)1387-1389
Number of pages3
JournalExperientia
Volume32
Issue number11
DOIs
StatePublished - Nov 1976
Externally publishedYes

Fingerprint

Dive into the research topics of 'Beta-adrenergic receptors in rat myocardium: Direct detection by a new fluorescent beta-blocker'. Together they form a unique fingerprint.

Cite this