Beneficial effect of magnesium sulfate in acute myocardial infarction

Michael Shechter*, Hanoch Hod, Nila Marks, Shlomo Behar, Elieser Kaplinsky, Babeth Rabinowitz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

The effects of magnesium on the incidence of arrhythmias and on mortality were evaluated in 103 patients with documented acute myocardial infarction (AMI) in a randomized, double-blind, placebo-controlled study. Fifty patients received a magnesium infusion for 48 hours and S3 received only the vehicle (isotonic glucose) as placebo. The baseline characteristics of the population were similar in the 2 groups. Tachyarrhythmias requiring drug therapy were recorded in 32% of the patients in the magnesium group and in 45% of the placebo group. Conduction disturbances were found in 23% of the placebo group as compared to 14% in the magnesium group. The intrahospital mortality was 2% (1 patient) in the magnesium group, compared to 17% (9 patients) in the placebo group (p < 0.01). No adverse effects were observed during and after the magnesium infusion. These data support a possible protective role of magnesium in patients with AMI.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalAmerican Journal of Cardiology
Volume66
Issue number3
DOIs
StatePublished - 1 Aug 1990

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