TY - JOUR
T1 - Beneficial and deleterious effects of cannabinoids in the brain
T2 - the case of ultra-low dose THC
AU - Sarne, Yosef
N1 - Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.
PY - 2019/11/2
Y1 - 2019/11/2
N2 - This article reviews the neurocognitive advantages and drawbacks of cannabinoid substances, and discusses the possible physiological mechanisms that underlie their dual activity. The article further reviews the neurocognitive effects of ultra-low doses of ∆9-tetrahydrocannabinol (THC; 3–4 orders of magnitude lower than the conventional doses) in mice, and proposes such low doses of THC as a possible remedy for various brain injuries and for the treatment of age-related cognitive decline.
AB - This article reviews the neurocognitive advantages and drawbacks of cannabinoid substances, and discusses the possible physiological mechanisms that underlie their dual activity. The article further reviews the neurocognitive effects of ultra-low doses of ∆9-tetrahydrocannabinol (THC; 3–4 orders of magnitude lower than the conventional doses) in mice, and proposes such low doses of THC as a possible remedy for various brain injuries and for the treatment of age-related cognitive decline.
KW - Tetrahydrocannabinol
KW - aging
KW - biphasic dose-dependency
KW - cognitive decline
KW - neuroprotection
KW - neurotoxicity
UR - http://www.scopus.com/inward/record.url?scp=85075457997&partnerID=8YFLogxK
U2 - 10.1080/00952990.2019.1578366
DO - 10.1080/00952990.2019.1578366
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
AN - SCOPUS:85075457997
SN - 0095-2990
VL - 45
SP - 551
EP - 562
JO - American Journal of Drug and Alcohol Abuse
JF - American Journal of Drug and Alcohol Abuse
IS - 6
ER -