TY - GEN
T1 - Behavioral rehabilitation of the eye closure reflex in senescent rats using a real-time biosignal acquisition system
AU - Prueckl, R.
AU - Taub, A. H.
AU - Herreros, I.
AU - Hogri, R.
AU - Magal, A.
AU - Bamford, S. A.
AU - Giovannucci, A.
AU - Almog, R. Ofek
AU - Shacham-Diamand, Y.
AU - Verschure, P. F.M.J.
AU - Mintz, M.
AU - Scharinger, J.
AU - Silmon, A.
AU - Guger, C.
PY - 2011
Y1 - 2011
N2 - In this paper the replacement of a lost learning function of rats through a computer-based real-time recording and feedback system is shown. In an experiment two recording electrodes and one stimulation electrode were implanted in an anesthetized rat. During a classical-conditioning paradigm, which includes tone and airpuff stimulation, biosignals were recorded and the stimulation events detected. A computational model of the cerebellum acquired the association between the stimuli and gave feedback to the brain of the rat using deep brain stimulation in order to close the eyelid of the rat. The study shows that replacement of a lost brain function using a direct bidirectional interface to the brain is realizable and can inspire future research for brain rehabilitation.
AB - In this paper the replacement of a lost learning function of rats through a computer-based real-time recording and feedback system is shown. In an experiment two recording electrodes and one stimulation electrode were implanted in an anesthetized rat. During a classical-conditioning paradigm, which includes tone and airpuff stimulation, biosignals were recorded and the stimulation events detected. A computational model of the cerebellum acquired the association between the stimuli and gave feedback to the brain of the rat using deep brain stimulation in order to close the eyelid of the rat. The study shows that replacement of a lost brain function using a direct bidirectional interface to the brain is realizable and can inspire future research for brain rehabilitation.
UR - http://www.scopus.com/inward/record.url?scp=84863591628&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2011.6091045
DO - 10.1109/IEMBS.2011.6091045
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C2 - 22255268
AN - SCOPUS:84863591628
SN - 9781424441211
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 4211
EP - 4214
BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
T2 - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Y2 - 30 August 2011 through 3 September 2011
ER -