BAT monoclonal antibody immunotherapy of human metastatic colorectal carcinoma in mice

Britta Hardy, Sara Morgenstern, Annat Raiter, Galina Rodionov, Ludmilla Fadaeev, Yaron Niv

Research output: Contribution to journalArticlepeer-review

Abstract

BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intravenous administration of both BAT antibodies significantly reduced the number of metastases and liver weights. Histological examinations demonstrated lymphocyte accumulation near remnant tumors and in tumor-free tissues of BAT treated mice. The efficacy of humanized BAT in the regression of hepatic metastases in human colorectal carcinoma has potential clinical use.

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalCancer Letters
Volume229
Issue number2
DOIs
StatePublished - 18 Nov 2005
Externally publishedYes

Keywords

  • BAT monoclonal antibody
  • Cancer immunotherapy
  • Liver histopathology
  • Liver metastases
  • Metastatic colorectal carcinoma
  • Mice tumor model

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