Basic and Non‐Basic Substrates of Carboxypeptidase B

Nava Zisapel*, Nurith Kurn‐Abramowitz, Mordechai Sokolovsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The kinetics of porcine‐carboxypeptidase‐B‐catalyzed hydrolysis of several N‐blocked peptides that differ in size and in C‐terminal amino acid were examined. The data demonstrate different kinetic behaviour of carboxypeptidase‐B‐catalyzed hydrolysis of basic and non‐basic substrates. These studies are consistent with our proposed multiple loci model. The results also show a number of differences between carboxypeptidases A and B, as well as several similarities.

Original languageEnglish
Pages (from-to)507-511
Number of pages5
JournalEuropean Journal of Biochemistry
Volume35
Issue number3
DOIs
StatePublished - Jun 1973

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