@article{a798ffd2804c46229fac35f247481f24,
title = "Basic and clinical significance of IGF-I-induced signatures in cancer",
abstract = "The insulin-like growth factor (IGF) system mediates growth, differentiation and developmental processes; it is also involved in various metabolic activities. Deregulation of IGF system expression and action is linked to diverse pathologies, ranging from growth deficits to cancer development. Targeting of the IGF axis emerged in recent years as a promising therapeutic approach in cancer and other medical conditions. Rational use of IGF-I-induced gene signatures may help to identify patients who might benefit from IGF axis-directed therapeutic modalities. In the accompanying research article in BMC Medicine, Rajski et al. show that IGF-I-induced gene expression in primary breast and lung fibroblasts accurately predict outcomes in breast and lung cancer patients.",
author = "Haim Werner and Ilan Bruchim",
note = "Funding Information: Work in HW's laboratory is supported by grants from the Insulin-Dependent Diabetes Trust (IDDT, UK) and the Israel Science Foundation. IB wishes to thank the Israel Cancer Research Fund (ICRF, Montreal, Canada) for their generous support.",
year = "2010",
month = jan,
day = "5",
doi = "10.1186/1741-7015-8-2",
language = "אנגלית",
volume = "8",
journal = "BMC Medicine",
issn = "1741-7015",
publisher = "BioMed Central Ltd.",
}