Basic and clinical significance of IGF-I-induced signatures in cancer

Haim Werner*, Ilan Bruchim

*Corresponding author for this work

Research output: Contribution to journalComment/debate

11 Scopus citations


The insulin-like growth factor (IGF) system mediates growth, differentiation and developmental processes; it is also involved in various metabolic activities. Deregulation of IGF system expression and action is linked to diverse pathologies, ranging from growth deficits to cancer development. Targeting of the IGF axis emerged in recent years as a promising therapeutic approach in cancer and other medical conditions. Rational use of IGF-I-induced gene signatures may help to identify patients who might benefit from IGF axis-directed therapeutic modalities. In the accompanying research article in BMC Medicine, Rajski et al. show that IGF-I-induced gene expression in primary breast and lung fibroblasts accurately predict outcomes in breast and lung cancer patients.

Original languageEnglish
Article number2
JournalBMC Medicine
StatePublished - 5 Jan 2010


FundersFunder number
Insulin-Dependent Diabetes Trust
Israel Cancer Research Fund
Israel Science Foundation


    Dive into the research topics of 'Basic and clinical significance of IGF-I-induced signatures in cancer'. Together they form a unique fingerprint.

    Cite this