TY - JOUR
T1 - Basaloid squamous carcinoma of the larynx
AU - Bahar, Gideon
AU - Feinmesser, Raphael
AU - Popovtzer, Aharon
AU - Ulanovsky, David
AU - Nageris, Ben
AU - Marshak, Gideon
AU - Feinmesser, Meora
N1 - Funding Information:
This work was supported by project grant C 90347 (ESA Prodex 9) and FWO 12K1416N postdoctoral fellowship at CmPA, KU Leuven. This work was partially co-funded by projects GOA/2015-014 (KU Leuven) and G.0A23.16N (FWO-Vlaanderen). This research has been funded by the Interuniversity Attraction Poles Programme initiated by the Belgian Science Policy Office (IAP P7/08 CHARM). The computational resources and services used in this work were provided by the VSC (Flemish Supercomputer Center), funded by the Research Foundation - Flanders (FWO) and the Flemish Government - department EWI. A.A.L. is grateful to the IWT PhD fellowship for the support during this research.
PY - 2003
Y1 - 2003
N2 - Background: Basaloid squamous cell carcinoma (BSCC) is a distinct variant of squamous cell carcinoma that was first described by Wain et al in 1986. Since then, about 160 cases have been reported in the literature. Only 40 cases have been described in the larynx. Methods: Four cases of BSCC of the larynx treated in our department between 1986 and 2000 are presented. The clinical features, biological behavior, and histopathological and immunohistochemical characteristics of this uncommon tumor are described, and the relevant literature is reviewed. Results: The main clinical presentation did not differ from other histological types of laryngeal carcinoma. The clinical course, however, was much more aggressive. All the patients received aggressive therapy including radical surgery and radiation. Two patients received chemotherapy. Two of the 4 patients presented died of distant metastasis shortly after diagnosis and treatment. Conclusions: The finding of this study with a limited number of patients supports previous reports suggesting that BSCC is a highly aggressive tumor that presents in older population with male predominance. The frequency of associated regional as well as distant metastases suggests that aggressive treatment is indicated and that systemic chemotherapy should be contemplated.
AB - Background: Basaloid squamous cell carcinoma (BSCC) is a distinct variant of squamous cell carcinoma that was first described by Wain et al in 1986. Since then, about 160 cases have been reported in the literature. Only 40 cases have been described in the larynx. Methods: Four cases of BSCC of the larynx treated in our department between 1986 and 2000 are presented. The clinical features, biological behavior, and histopathological and immunohistochemical characteristics of this uncommon tumor are described, and the relevant literature is reviewed. Results: The main clinical presentation did not differ from other histological types of laryngeal carcinoma. The clinical course, however, was much more aggressive. All the patients received aggressive therapy including radical surgery and radiation. Two patients received chemotherapy. Two of the 4 patients presented died of distant metastasis shortly after diagnosis and treatment. Conclusions: The finding of this study with a limited number of patients supports previous reports suggesting that BSCC is a highly aggressive tumor that presents in older population with male predominance. The frequency of associated regional as well as distant metastases suggests that aggressive treatment is indicated and that systemic chemotherapy should be contemplated.
UR - http://www.scopus.com/inward/record.url?scp=0038475783&partnerID=8YFLogxK
U2 - 10.1016/S0196-0709(03)00004-8
DO - 10.1016/S0196-0709(03)00004-8
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AN - SCOPUS:0038475783
SN - 0196-0709
VL - 24
SP - 204
EP - 208
JO - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
JF - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
IS - 3
ER -