Basal ganglia oscillations and pathophysiology of movement disorders

Michal Rivlin-Etzion; Odeya Marmor; Gali Heimer; Aeyal Raz; Asaph Nini; Hagai Bergman

doi:10.1016/j.conb.2006.10.002

Basal ganglia oscillations and pathophysiology of movement disorders

Michal Rivlin-Etzion^*, Odeya Marmor, Gali Heimer, Aeyal Raz, Asaph Nini, Hagai Bergman

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

166 Scopus citations

Abstract

Low frequency rest tremor is one of the cardinal signs of Parkinson's disease and some of its animal models. Current physiological studies and models of the basal ganglia differ as to which aspects of neuronal activity are crucial to the pathophysiology of Parkinson's disease. There is evidence that neural oscillations and synchronization play a central role in the generation of the disease. However, parkinsonian tremor is not strictly correlated with the synchronous oscillations in the basal ganglia networks. Rather, abnormal basal ganglia output enforces abnormal thalamo-cortical processing leading to akinesia, the main negative symptom of Parkinson's disease. Parkinsonian tremor has probably evolved as a downstream compensatory mechanism.

Original language	English
Pages (from-to)	629-637
Number of pages	9
Journal	Current Opinion in Neurobiology
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.conb.2006.10.002
State	Published - Dec 2006
Externally published	Yes

Funding

Funders	Funder number
Hebrew University Netherlands Association
Israel Science Foundation

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10.1016/j.conb.2006.10.002

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title = "Basal ganglia oscillations and pathophysiology of movement disorders",

abstract = "Low frequency rest tremor is one of the cardinal signs of Parkinson's disease and some of its animal models. Current physiological studies and models of the basal ganglia differ as to which aspects of neuronal activity are crucial to the pathophysiology of Parkinson's disease. There is evidence that neural oscillations and synchronization play a central role in the generation of the disease. However, parkinsonian tremor is not strictly correlated with the synchronous oscillations in the basal ganglia networks. Rather, abnormal basal ganglia output enforces abnormal thalamo-cortical processing leading to akinesia, the main negative symptom of Parkinson's disease. Parkinsonian tremor has probably evolved as a downstream compensatory mechanism.",

author = "Michal Rivlin-Etzion and Odeya Marmor and Gali Heimer and Aeyal Raz and Asaph Nini and Hagai Bergman",

note = "Funding Information: This research was supported in part by a Center of Excellence grant from the Israel Science Foundation (ISF) and the {\textquoteleft}Fighting against Parkinson{\textquoteright} Foundation of the Hebrew University Netherlands Association (HUNA). We thank E Singer for critical reading and language editing.",

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AU - Marmor, Odeya

AU - Heimer, Gali

AU - Raz, Aeyal

AU - Nini, Asaph

AU - Bergman, Hagai

N1 - Funding Information: This research was supported in part by a Center of Excellence grant from the Israel Science Foundation (ISF) and the ‘Fighting against Parkinson’ Foundation of the Hebrew University Netherlands Association (HUNA). We thank E Singer for critical reading and language editing.

PY - 2006/12

Y1 - 2006/12

N2 - Low frequency rest tremor is one of the cardinal signs of Parkinson's disease and some of its animal models. Current physiological studies and models of the basal ganglia differ as to which aspects of neuronal activity are crucial to the pathophysiology of Parkinson's disease. There is evidence that neural oscillations and synchronization play a central role in the generation of the disease. However, parkinsonian tremor is not strictly correlated with the synchronous oscillations in the basal ganglia networks. Rather, abnormal basal ganglia output enforces abnormal thalamo-cortical processing leading to akinesia, the main negative symptom of Parkinson's disease. Parkinsonian tremor has probably evolved as a downstream compensatory mechanism.

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Basal ganglia oscillations and pathophysiology of movement disorders

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