Banyasin A and banyasides A and B, three novel modified peptides from a water bloom of the cyanobacterium Nostoc sp.

Alexey Pluotno, Shmuel Carmeli

Research output: Contribution to journalArticlepeer-review

Abstract

Three new modified peptides banyasin A, banyaside A and banyaside B were isolated from the hydrophilic extract of a natural bloom of the cyanobacterium Nostoc sp. The planar structure of the new compounds was determined by homonuclear and inverse-heteronuclear 2D NMR techniques as well as high-resolution mass spectrometry. Banyasides A and B, are structurally closely related to the cyanobacteria metabolite, suomilide and to the sponge derived, dysinosins. The absolute configuration of the asymmetric centers was studied using Marfey's method for HPLC. Banyaside A and B were found to be trypsin and thrombin inhibitors. Graphical Abstract.

Original languageEnglish
Pages (from-to)575-583
Number of pages9
JournalTetrahedron
Volume61
Issue number3
DOIs
StatePublished - 17 Jan 2005

Funding

FundersFunder number
European CommunityERBIC18-CT98-0293
Tel Aviv University
Ministry of Science and Technology, Israel432-201

    Keywords

    • Cyanobacteria
    • Natural products
    • Nostoc
    • Protease inhibitors

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