TY - JOUR
T1 - Banking on a new understanding
T2 - translational opportunities from veterinary biobanks
AU - Dog Aging Project Consortium
AU - LaLonde-Paul, D.
AU - Mouttham, L.
AU - Akey, Joshua M.
AU - Benton, Brooke
AU - Borenstein, Elhanan
AU - Coleman, Amanda E.
AU - Creevy, Kate E.
AU - Crowder, Kyle
AU - Dunbar, Matthew D.
AU - Fajt, Virginia R.
AU - Fitzpatrick, Annette L.
AU - Jeffery, Unity
AU - Jonlin, Erica C.
AU - Kaeberlein, Matt
AU - Karlsson, Elinor K.
AU - Kerr, Kathleen F.
AU - Levine, Jonathan M.
AU - Ma, Jing
AU - McClelland, Robyn L.
AU - Ruple, Audrey
AU - Schwartz, Stephen M.
AU - Shrager, Sandi
AU - Snyder-Mackler, Noah
AU - Tolbert, M. Katherine
AU - Urfer, Silvan R.
AU - Wilfond, Benjamin S.
AU - Promislow, D. E.L.
AU - Castelhano, M. G.
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to American Aging Association.
PY - 2023/6
Y1 - 2023/6
N2 - Current advances in geroscience are due in part to the discovery of biomarkers with high predictive ability in short-lived laboratory animals such as flies and mice. These model species, however, do not always adequately reflect human physiology and disease, highlighting the need for a more comprehensive and relevant model of human aging. Domestic dogs offer a solution to this obstacle, as they share many aspects not only of the physiological and pathological trajectories of their human counterpart, but also of their environment. Furthermore, they age at a considerably faster rate. Studying aging in the companion dog provides an opportunity to better understand the biological and environmental determinants of healthy lifespan in our pets, and to translate those findings to human aging. Biobanking, the systematic collection, processing, storage, and distribution of biological material and associated data has contributed to basic, clinical, and translational research by streamlining the management of high-quality biospecimens for biomarker discovery and validation. In this review, we discuss how veterinary biobanks can support research on aging, particularly when integrated into large-scale longitudinal studies. As an example of this concept, we introduce the Dog Aging Project Biobank.
AB - Current advances in geroscience are due in part to the discovery of biomarkers with high predictive ability in short-lived laboratory animals such as flies and mice. These model species, however, do not always adequately reflect human physiology and disease, highlighting the need for a more comprehensive and relevant model of human aging. Domestic dogs offer a solution to this obstacle, as they share many aspects not only of the physiological and pathological trajectories of their human counterpart, but also of their environment. Furthermore, they age at a considerably faster rate. Studying aging in the companion dog provides an opportunity to better understand the biological and environmental determinants of healthy lifespan in our pets, and to translate those findings to human aging. Biobanking, the systematic collection, processing, storage, and distribution of biological material and associated data has contributed to basic, clinical, and translational research by streamlining the management of high-quality biospecimens for biomarker discovery and validation. In this review, we discuss how veterinary biobanks can support research on aging, particularly when integrated into large-scale longitudinal studies. As an example of this concept, we introduce the Dog Aging Project Biobank.
KW - Aging
KW - Biobank
KW - Dogs
KW - Geroscience
KW - Translational research
KW - Veterinary
UR - http://www.scopus.com/inward/record.url?scp=85149661170&partnerID=8YFLogxK
U2 - 10.1007/s11357-023-00763-z
DO - 10.1007/s11357-023-00763-z
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C2 - 36890420
AN - SCOPUS:85149661170
SN - 2509-2715
VL - 45
SP - 1439
EP - 1450
JO - GeroScience
JF - GeroScience
IS - 3
ER -